Pühringer Vanessa, Jilma Bernd, Herkner Harald
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
Front Allergy. 2023 Dec 12;4:1249280. doi: 10.3389/falgy.2023.1249280. eCollection 2023.
It is extremely difficult to compare studies investigating the frequency of anaphylaxis making it challenging to satisfactorily assess the worldwide incidence rate. Using a systematic review and meta-analysis, this publication aims to determine the current incidence of all-cause anaphylaxis worldwide. Additionally, we investigated whether the incidence of anaphylaxis has changed over time and which factors influence the rates determined by individual studies.
A literature search was performed in four databases. All articles that reported relevant information on population-based incidence rates of all-cause anaphylaxis were included. The protocol was published on INPLASY, the International Platform of Registered Systematic Review and Meta-analysis Protocols.
The database query and screening process resulted in 46 eligible articles on anaphylaxis. The current incidence worldwide was found to be approximately 46 cases per 100,000 population per year (95% CI 21-103). Evaluating confounding factors showed that studies using allergy clinics and hospitalizations as data source result in comparably low rates. Moreover, children are less prone to develop anaphylaxis compared to the general population. Using a random effects Poisson model we calculated a yearly increase of anaphylaxis incidence by 7.4% (95% CI 7.3-7.6, < 0.05).
This seems to be the first approach to analyze every reported all-cause anaphylaxis incidence rate until 2017 for an at most accurate determination of its epidemiology. Based on these results, future research could investigate the underlying causes for the rising incidence in order find ways to decrease the condition's frequency.
inplasy.com, identifier [INPLASY202330047].
比较研究过敏性反应发生频率的各项研究极具难度，这使得令人满意地评估全球发病率颇具挑战。本出版物旨在通过系统评价和荟萃分析来确定全球范围内全因性过敏性反应的当前发病率。此外，我们还研究了过敏性反应的发病率是否随时间变化，以及哪些因素会影响个别研究确定的发病率。
在四个数据库中进行了文献检索。纳入所有报告了基于人群的全因性过敏性反应发病率相关信息的文章。该方案已在国际注册系统评价和荟萃分析方案平台INPLASY上发表。
数据库查询和筛选过程产生了46篇关于过敏性反应的合格文章。发现全球目前的发病率约为每年每10万人中有46例（95%置信区间21 - 103）。对混杂因素的评估表明，以过敏诊所和住院病例作为数据源的研究得出的发病率相对较低。此外，与普通人群相比，儿童发生过敏性反应的可能性较小。使用随机效应泊松模型，我们计算出过敏性反应发病率每年增加7.4%（95%置信区间7.3 - 7.6，P < 0.05）。
这似乎是首次对截至2017年每一项报告的全因性过敏性反应发病率进行分析，以最准确地确定其流行病学情况。基于这些结果，未来的研究可以调查发病率上升的潜在原因，以便找到降低该疾病发生率的方法。
inplasy.com，标识符[INPLASY20233'0047]
