毒蕈碱受体对牛肾上腺中[Met5]脑啡肽免疫反应性物质和儿茶酚胺释放的调节作用。

Muscarinic receptor modulation of release of [Met5]enkephalin immunoreactive material and catecholamines from the bovine adrenal gland.

作者信息

Barron B A, Hexum T D

出版信息

Br J Pharmacol. 1986 Dec;89(4):713-8. doi: 10.1111/j.1476-5381.1986.tb11175.x.

DOI:10.1111/j.1476-5381.1986.tb11175.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917244/

Abstract

Muscarinic receptor modulation of secretion from the adrenal medulla was studied using retrogradely perfused bovine tissue. Atropine, at a dose not affecting 1,1 dimethyl-4-phenylpiperizinium (DMPP)-stimulated release, inhibited the acetylcholine (ACh)-stimulated release of noradrenaline and [Met5]enkephalin-immunoreactive material (ME-IRM). DMPP-stimulated release of catecholamines and ME-IRM was potentiated by the addition of methacholine. Pilocarpine significantly potentiated the release of noradrenaline only. Methacholine, pilocarpine or muscarine, when infused alone, had no stimulatory affect on the basal release of ME-IRM. These findings suggest that the muscarinic receptors in the bovine adrenal medulla function by potentiating the release of ME-IRM and catecholamines induced by nicotinic receptor stimulation.

摘要

利用逆行灌注的牛组织研究了毒蕈碱受体对肾上腺髓质分泌的调节作用。阿托品在不影响1,1 - 二甲基 - 4 - 苯基哌嗪鎓（DMPP）刺激释放的剂量下，抑制了乙酰胆碱（ACh）刺激的去甲肾上腺素和[Met5]脑啡肽免疫反应性物质（ME - IRM）的释放。加入乙酰甲胆碱可增强DMPP刺激的儿茶酚胺和ME - IRM的释放。毛果芸香碱仅显著增强了去甲肾上腺素的释放。当单独注入乙酰甲胆碱、毛果芸香碱或毒蕈碱时，对ME - IRM的基础释放没有刺激作用。这些发现表明，牛肾上腺髓质中的毒蕈碱受体通过增强烟碱受体刺激诱导的ME - IRM和儿茶酚胺的释放来发挥作用。

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本文引用的文献

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CATECHOLAMINE RELEASE FROM THE ISOLATED PERFUSED ADRENAL GLAND.从离体灌注肾上腺释放儿茶酚胺。

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Catecholamine secretion by perfused bovine adrenal medulla in response to nicotinic activation is inhibited by muscarinic receptors.灌注的牛肾上腺髓质对烟碱激活的反应所分泌的儿茶酚胺受到毒蕈碱受体的抑制。

Biochem Pharmacol. 1983 Dec 15;32(24):3873-4. doi: 10.1016/0006-2952(83)90166-1.

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Both nicotinic and muscarinic receptors mediate catecholamine secretion by isolated guinea-pig chromaffin cells.烟碱型受体和毒蕈碱型受体均可介导豚鼠离体嗜铬细胞的儿茶酚胺分泌。

Neuroscience. 1983 Nov;10(3):979-85. doi: 10.1016/0306-4522(83)90236-1.

9

Release of catecholamines and [Met5]enkephalin immunoreactive material from perfused bovine adrenal glands.灌注牛肾上腺中儿茶酚胺和[Met5]脑啡肽免疫反应性物质的释放。

Eur J Pharmacol. 1984 Nov 27;106(3):593-9. doi: 10.1016/0014-2999(84)90063-3.

10

Stability of bovine adrenal medulla cells in culture.培养中牛肾上腺髓质细胞的稳定性。

J Neurochem. 1980 Sep;35(3):679-92. doi: 10.1111/j.1471-4159.1980.tb03707.x.

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