血清中外泌体circSCMH1与miR-874的比值用于预测颈动脉和冠状动脉斑块稳定性。

Exosomal circSCMH1/miR-874 ratio in serum to predict carotid and coronary plaque stability.

作者信息

Wang Jiayu, Liu Yixuan, Tian Peiqing, Xing Liyun, Huang Xianwei, Fu Caihua, Xu Xiangyu, Liu Ping

机构信息

Department of Cardiology, The Second Hospital of Shandong University, Shandong, China.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.

出版信息

Front Cardiovasc Med. 2023 Dec 11;10:1277427. doi: 10.3389/fcvm.2023.1277427. eCollection 2023.

DOI:10.3389/fcvm.2023.1277427

PMID:38149265

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10750349/

Abstract

BACKGROUND

To investigate the correlation between lg (circSCMH1/miR-874) and acute coronary syndrome (ACS), acute myocardial infarction (AMI), and carotid plaque stability.

METHODS

701 patients were divided into stable coronary artery disease (SCAD), ACS, and control groups. Furthermore, 225 patients who underwent carotid ultrasound were selected from the above 701 patients and were divided into low-risk plaque, medium-to-high risk plaque, and control (without carotid plaques) groups. We collected their baseline characteristics and measured the contents of exosomal circSCMH1 and miR-874 in peripheral blood. Then lg(circSCMH1/miR-874) was calculated and statistical analysis was performed.

RESULTS

The lg (circSCMH1/miR-874) values of ACS, SCAD, and the control group decreased successively ( < 0.05). Compared with the low-risk plaque and control groups, the lg (circSCMH1/miR-874) value of medium-high risk plaque group decreased ( < 0.05). Multivariate logistic regression analysis showed that with the decrease of lg (circSCMH1/miR-874), the risk of ACS, AMI, and medium-high risk plaques increased. ROC curve analysis demonstrated that lg (circSCMH1/miR-874) has a higher diagnostic value for ACS, AMI and medium-high risk plaques than previously used predictive ratios.

CONCLUSION

Lg (circSCMH1/miR-874) is closely associated with coronary and carotid plaque stability.

摘要

背景

探讨lg（circSCMH1/miR - 874）与急性冠状动脉综合征（ACS）、急性心肌梗死（AMI）及颈动脉斑块稳定性之间的相关性。

方法

将701例患者分为稳定型冠心病（SCAD）组、ACS组和对照组。此外，从上述701例患者中选取225例行颈动脉超声检查的患者，分为低风险斑块组、中高风险斑块组和对照组（无颈动脉斑块）。收集其基线特征，并检测外周血中外泌体circSCMH1和miR - 874的含量。然后计算lg（circSCMH1/miR - 874）并进行统计分析。

结果

ACS组、SCAD组和对照组的lg（circSCMH1/miR - 874）值依次降低（P<0.05）。与低风险斑块组和对照组相比，中高风险斑块组的lg（circSCMH1/miR - 874）值降低（P<0.05）。多因素logistic回归分析显示，随着lg（circSCMH1/miR - 874）的降低，ACS、AMI及中高风险斑块的风险增加。ROC曲线分析表明，lg（circSCMH1/miR - 874）对ACS、AMI和中高风险斑块的诊断价值高于先前使用的预测指标。