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乳糜泻与原发性甲状旁腺功能亢进症。

Celiac disease and primary hyperparathyroidism.

机构信息

Hospital Privado de Rosario.

Unidad de Tiroides y Paratiroides del Grupo Gamma.

出版信息

Rev Fac Cien Med Univ Nac Cordoba. 2023 Dec 26;80(4):499-509. doi: 10.31053/1853.0605.v80.n4.42137.

DOI:10.31053/1853.0605.v80.n4.42137
PMID:38150201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10851394/
Abstract

OBJECTIVE

Primary hyperparathyroidism (PHPT) and celiac disease (CD) are two distinct medical conditions that can affect bone health. While PHPT leads to excessive calcium levels and bone abnormalities, CD impairs calcium and vitamin D absorption due to small intestine damage.

CASE REPORT

We present a case of a 49-year-old woman diagnosed with osteoporosis who was found to have both PHPT and CD. The patient underwent a successful minimally invasive parathyroidectomy, which resulted in decreased parathyroid hormone levels.

CONCLUSION

This case highlights the rare coexistence of PHPT and CD and emphasizes the importance of considering secondary causes of osteoporosis in patients with low bone mass. Further studies are needed to explore the underlying mechanisms and potential links between PHPT and CD.

摘要

目的

原发性甲状旁腺功能亢进症(PHPT)和乳糜泻(CD)是两种不同的医学病症,均可影响骨骼健康。PHPT 导致钙水平过高和骨骼异常,而 CD 则由于小肠损伤而影响钙和维生素 D 的吸收。

病例报告

我们介绍了一位 49 岁女性骨质疏松症患者的病例,她同时被诊断出患有 PHPT 和 CD。患者接受了成功的微创甲状旁腺切除术,甲状旁腺激素水平降低。

结论

本病例强调了 PHPT 和 CD 罕见共存的情况,并强调了在低骨量患者中考虑骨质疏松症继发原因的重要性。需要进一步研究以探讨 PHPT 和 CD 之间的潜在机制和联系。

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本文引用的文献

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AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS- 2020 UPDATE .美国临床内分泌医师协会/美国内分泌学会 2020 年绝经后骨质疏松症诊断和治疗临床实践指南更新版
Endocr Pract. 2020 May;26(5):564-570. doi: 10.4158/GL-2020-0524.
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Primary Hyperparathyroidism.原发性甲状旁腺功能亢进症。
J Clin Endocrinol Metab. 2018 Nov 1;103(11):3993-4004. doi: 10.1210/jc.2018-01225.
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Predictors of improvement in bone mineral density after celiac disease diagnosis.
乳糜泻诊断后骨密度改善的预测因素。
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Coeliac disease.乳糜泻
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Bone and Celiac Disease.骨骼与乳糜泻
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Extraintestinal manifestations of coeliac disease.肠外麸质疾病相关性表现。
Nat Rev Gastroenterol Hepatol. 2015 Oct;12(10):561-71. doi: 10.1038/nrgastro.2015.131. Epub 2015 Aug 11.
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Primary hyperparathyroidism and celiac disease: a population-based cohort study.原发性甲状旁腺功能亢进症与乳糜泻:一项基于人群的队列研究。
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Parathyroidectomy improves bone geometry and microarchitecture in female patients with primary hyperparathyroidism: a one-year prospective controlled study using high-resolution peripheral quantitative computed tomography.甲状旁腺切除术改善原发性甲状旁腺功能亢进症女性患者的骨几何和微结构:一年前瞻性对照研究使用高分辨率外周定量计算机断层扫描。
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