Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India.
Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee 247667, India.
Inorg Chem. 2024 Jan 8;63(1):714-729. doi: 10.1021/acs.inorgchem.3c03665. Epub 2023 Dec 27.
Ligands derived from 2-(1-phenylhydrazinyl)pyridine and salicylaldehyde (HL), 3-methoxysalicylaldehyde (HL), 5-bromosalicylaldehyde (HL), and 3,5-di--butylsalicylaldehyde (HL) react with [VO(acac)] in MeOH followed by aerial oxidation to give [VO(L)] (), [VO(L)] (), [VO(L)] (), and [VO(L)] (). Complex [VO(acac)(L)] () is also isolable from [VO(acac)] and HL in dry MeOH. Structures of all complexes were confirmed by single-crystal X-ray and spectroscopic studies. They efficiently catalyze benzyl alcohol and its derivatives' oxidation in the presence of HO to their corresponding aldehydes. Under optimized reaction conditions using as a catalyst precursor, conversion of benzyl alcohol follows the order: (93%) > (90%) > (86%) > (84%) ≈ (84%). These complexes were also evaluated for antifungal and antiproliferative activities. Complex with MIC = 16 μg/mL, with MIC = 12 μg/mL, and with MIC = 16 μg/mL are efficient toward planktonic cells of and . On Michigan cancer foundation-7 (MCF-7) cells, they show comparable cytotoxic effects and exhibit IC in the 27.3-33.5 μg/mL range, and among these, exhibits the highest cytotoxicity. A similar study on human embryonic kidney cells (HEK293) confirms their less toxicity at lower concentrations (4 to 16 μg/mL) compared to MCF-7.
配体衍生自 2-(1-苯腙基)吡啶和水杨醛 (HL)、3-甲氧基水杨醛 (HL)、5-溴水杨醛 (HL) 和 3,5-二-叔丁基水杨醛 (HL)，在 MeOH 中与 [VO(acac)] 反应，然后进行空气氧化，得到 [VO(L)] (), [VO(L)] (), [VO(L)] (), 和 [VO(L)] (). 配合物 [VO(acac)(L)] () 也可以从 [VO(acac)] 和 HL 在干燥的 MeOH 中分离得到。所有配合物的结构均通过单晶 X 射线和光谱研究得到证实。它们在 HO 的存在下有效地催化苄醇及其衍生物氧化为相应的醛。在使用 作为催化剂前体的最佳反应条件下，苄醇的转化率遵循以下顺序： (93%) > (90%) > (86%) > (84%) ≈ (84%). 这些配合物还评估了其抗真菌和抗增殖活性。具有 MIC = 16 μg/mL 的 、MIC = 12 μg/mL 的 以及 MIC = 16 μg/mL 的 对 和 的浮游细胞有效。在密歇根癌症基金会-7 (MCF-7) 细胞上，它们对细胞的细胞毒性作用相当，并表现出在 27.3-33.5 μg/mL 范围内的 IC，其中 表现出最高的细胞毒性。在人胚肾细胞 (HEK293) 上进行的类似研究证实，与 MCF-7 相比，它们在较低浓度（4 至 16 μg/mL）下的毒性较小。
