大鼠脉络丛中5-HT-1c受体的去神经超敏反应。
Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus.
作者信息
Conn P J, Janowsky A, Sanders-Bush E
出版信息
Brain Res. 1987 Jan 6;400(2):396-8. doi: 10.1016/0006-8993(87)90641-x.
PMID:3815085
Abstract
Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. The current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-HT and a supersensitive 5-HT-1c mediated phosphoinositide hydrolysis response. These data suggest that the 5-HT-1c site in choroid plexus receives tonic serotonergic input.
摘要
血清素（5-羟色胺，5-HT）刺激脉络丛中的磷酸肌醇水解是由5-HT-1c受体介导的。当前研究表明，用血清素能神经毒素5,7-二羟基色胺处理大鼠，会导致5-HT显著耗竭以及5-HT-1c介导的磷酸肌醇水解反应超敏。这些数据表明，脉络丛中的5-HT-1c位点接受紧张性血清素能输入。
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