Mukamel E, deKernion J B, Hannah J, Smith R B, Skinner D G, Goodwin W E
Cancer. 1987 Apr 15;59(8):1535-8. doi: 10.1002/1097-0142(19870415)59:8<1535::aid-cncr2820590825>3.0.co;2-#.
The incidence and significance of seminal vesicle invasion in patients with adenocarcinoma of the prostate were determined in 139 patients who underwent radical prostatectomy. Of the 36 patients who had seminal vesicle invasion, 27 (75%) also had capsular invasion and 13 (43%) had lymph node metastases. Disease progression rates were 31% and 58% at 5 and 8 years, respectively. Survival rate at 5 years was 90.6% and at 8 years it was 83.7%. Of the 103 patients without seminal vesicle invasion, 21 (20.4%) also had capsular invasion and 11 (12%) had lymph node metastases. Disease progression rates were 2.5% and 15.7% at 5 and 8 years, respectively. Survival rate at both 5 and 8 years was 98.4%. These data suggest that the majority of patients with seminal invasion do not have lymph node metastases on presentation and thus they cannot be detected by lymph node dissection before radical prostatectomy. Improved techniques for preoperative detection of seminal vesicle invasion can assist in patient selection for surgery and improve the results of radical prostatectomy.
对139例行根治性前列腺切除术的患者，确定了前列腺腺癌患者精囊侵犯的发生率及意义。在36例有精囊侵犯的患者中，27例（75%）也有包膜侵犯，13例（43%）有淋巴结转移。5年和8年时的疾病进展率分别为31%和58%。5年生存率为90.6%，8年生存率为83.7%。在103例无精囊侵犯的患者中，21例（20.4%）也有包膜侵犯，11例（12%）有淋巴结转移。5年和8年时的疾病进展率分别为2.5%和15.7%。5年和8年的生存率均为98.4%。这些数据表明，大多数有精囊侵犯的患者在初诊时无淋巴结转移，因此在根治性前列腺切除术前行淋巴结清扫无法检测到。改进术前检测精囊侵犯的技术有助于手术患者的选择，并改善根治性前列腺切除术的效果。
