Kornstein M J, Stewart R, Elder D E
Cancer Res. 1987 Mar 1;47(5):1411-2.
Using an immunoperoxidase technique, we have investigated natural killer (NK) cells in the host response to malignant melanomas and melanocytic nevi in frozen sections. Eight primary melanomas, 12 metastatic melanomas, and 31 dysplastic nevi were studied. NK cells were identified phenotypically using an antibody, B73.1, against an Fc receptor present only on NK cells and neutrophils. Rare NK cells were identified in three of 31 dysplastic nevi and in one of eight melanomas. In contrast, significant numbers of NK cells were identified in ten of 12 metastases.
我们采用免疫过氧化物酶技术，在冷冻切片中研究了宿主对恶性黑色素瘤和黑素细胞痣的反应中的自然杀伤（NK）细胞。研究了8例原发性黑色素瘤、12例转移性黑色素瘤和31例发育异常痣。使用一种针对仅存在于NK细胞和中性粒细胞上的Fc受体的抗体B73.1对NK细胞进行表型鉴定。在31例发育异常痣中的3例和8例黑色素瘤中的1例中发现了罕见的NK细胞。相比之下，在12例转移瘤中的10例中发现了大量的NK细胞。
