Affiliated Hospital of Jiangnan University, Wuxi, China; Nantong University, Nantong, China.
Affiliated Hospital of Jiangnan University, Wuxi, China; Nantong University, Nantong, China; Wuxi School of Medicine, Jiangnan University, Wuxi, China.
J Steroid Biochem Mol Biol. 2024 Mar;237:106451. doi: 10.1016/j.jsbmb.2023.106451. Epub 2023 Dec 26.
Understanding the sexual dimorphism in diseases is essential to investigate the pathogenesis of some chronic diseases (e.g., autoimmune diseases, etc). The gut microbiota has been found to show a notable impact on the pathology of several chronic diseases in recent years. Intriguingly, the composition of the gut microbiota varies between sexes. Here, we reviewed 'facts and fiction' regarding sexual dimorphism in chronic diseases and sexual dimorphism in the gut microbiota respectively. The association and causative relationship between them aiming to elucidate the pathological mechanisms of sexual dimorphism in chronic diseases were further explored. The development of gender-special food products based on the sexual dimorphism in the gut microbiota were recommended, which would be beneficial to facilitating the personalized treatment.
了解疾病中的性别二态性对于研究某些慢性疾病（例如自身免疫性疾病等）的发病机制至关重要。近年来，人们发现肠道微生物群对多种慢性疾病的病理具有显著影响。有趣的是，肠道微生物群的组成在性别之间存在差异。在这里，我们分别回顾了慢性疾病中的性别二态性和肠道微生物群中的性别二态性的“事实和虚构”。进一步探讨了它们之间的关联和因果关系，旨在阐明慢性疾病中性别二态性的病理机制。我们还推荐了基于肠道微生物群中的性别二态性开发性别特异性食品产品，这将有助于促进个性化治疗。
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