具有透明细胞特征和 EWSR1 重排的癌：3 例报告。

Carcinomas with clear cell features and EWSR1 rearrangements: a report of 3 cases.

机构信息

Department of Oral Pathology, School of Oral Health Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Department of Anatomical Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2024 Aug;138(2):293-300. doi: 10.1016/j.oooo.2023.11.010. Epub 2023 Nov 25.

DOI:10.1016/j.oooo.2023.11.010

PMID:38155013

Abstract

Salivary gland and odontogenic neoplasms with extensive clear cell change are rare lesions but have been increasingly characterized over the past decade. Among this heterogeneous group of neoplasms, hyalinizing clear cell carcinoma (HCCC), clear cell odontogenic carcinoma (CCOC), and clear cell myoepithelial carcinoma (CCMC) share a monophasic clear cell morphology and an EWSR1 gene rearrangement. While HCCC is relatively well characterized, there are a limited number of EWSR1-reaarranged CCMC of salivary glands reported, and its clinicopathologic features in relation to HCCC and nonclear cell myoepithelial carcinoma (MC) have not been clarified. This report describes the clinical, morphologic, and immunophenotypic features of 3 carcinomas composed predominantly of clear cells and with EWSR1 rearrangements by fluorescence in situ hybridization. A comparative literature analysis suggests that HCCC, CCMC, and nonclear cell MC of salivary glands are clinically, histopathologically, and molecularly distinct.

摘要

具有广泛透明细胞改变的唾液腺和牙源性肿瘤是罕见的病变，但在过去十年中已越来越多地被描述。在这组异质性肿瘤中，透明细胞癌（HCCC）、透明细胞牙源性癌（CCOC）和透明细胞肌上皮癌（CCMC）具有单相透明细胞形态和 EWSR1 基因重排。虽然 HCCC 已得到较好的描述，但报道的唾液腺 EWSR1 重排的 CCMC 数量有限，其与 HCCC 和非透明细胞肌上皮癌（MC）的临床病理特征尚未阐明。本报告描述了通过荧光原位杂交显示主要由透明细胞组成且具有 EWSR1 重排的 3 种癌的临床、形态和免疫表型特征。文献比较分析表明，唾液腺的 HCCC、CCMC 和非透明细胞 MC 在临床、组织病理学和分子水平上是不同的。