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Refractory hemophagocytic lymphohistiocytosis secondary to polatuzumab vedotin plus rituximab and bendamustine.

作者信息

Lv Kebing, Kong Fancong, Yu Min, Zhou Yulan, Li Fei

机构信息

Center of Hematology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwai StreetDonghu District, Nanchang, 330006, Jiangx, China.

Jiangxi Clinical Research Center for Hematologic Disease, Nanchang, China.

出版信息

Ann Hematol. 2024 Mar;103(3):1017-1019. doi: 10.1007/s00277-023-05598-4. Epub 2023 Dec 29.

DOI:10.1007/s00277-023-05598-4
PMID:38155243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10866743/
Abstract
摘要

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Refractory hemophagocytic lymphohistiocytosis secondary to polatuzumab vedotin plus rituximab and bendamustine.泊洛妥珠单抗联合利妥昔单抗和苯达莫司汀继发的难治性噬血细胞性淋巴组织细胞增生症
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[Efficacy and safety of Polatuzumab Vedotin in combination with rituximab plus bendamustine in patients with relapsed/refractory diffuse large B-cell lymphoma: a single center analysis].泊洛妥珠单抗联合利妥昔单抗及苯达莫司汀治疗复发/难治性弥漫性大B细胞淋巴瘤患者的疗效和安全性:一项单中心分析
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Poor clinical outcome of relapsed/refractory diffuse large B-cell lymphoma with MYC translocation treated with polatuzumab vedotin, bendamustine, and rituximab.复发/难治性伴有MYC易位的弥漫性大B细胞淋巴瘤采用泊洛妥珠单抗、苯达莫司汀和利妥昔单抗治疗的临床结局较差。
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Polatuzumab vedotin combined with rituximab-bendamustine immediately before stem cell mobilization in relapsed diffuse large B-cell lymphoma.在复发的弥漫性大B细胞淋巴瘤中,在干细胞动员前立即使用泊洛妥珠单抗维达汀联合利妥昔单抗-苯达莫司汀。
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Polatuzumab vedotin plus bendamustine and rituximab (Pola-BR) was effective for neurolymphomatosis in a patient with refractory diffuse large B-cell lymphoma.泊洛妥珠单抗联合苯达莫司汀和利妥昔单抗(Pola-BR)对一名难治性弥漫性大B细胞淋巴瘤患者的神经淋巴瘤有效。
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引用本文的文献

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Promising Targeted Therapies for Hemophagocytic Lymphohistiocytosis: A Translational Perspective Based on Immunopathology.噬血细胞性淋巴组织细胞增生症的有前景的靶向治疗:基于免疫病理学的转化视角
Clin Rev Allergy Immunol. 2025 Jun 9;68(1):56. doi: 10.1007/s12016-025-09068-9.

本文引用的文献

1
Systemic inflammatory syndromes as life-threatening side effects of immune checkpoint inhibitors: case report and systematic review of the literature.免疫检查点抑制剂的致命性系统性炎症综合征:病例报告和文献系统评价。
J Immunother Cancer. 2023 Mar;11(3). doi: 10.1136/jitc-2022-005841.
2
Polatuzumab vedotin to treat relapsed or refractory diffuse large B-cell lymphoma, in combination with bendamustine plus rituximab.泊洛妥珠单抗联合苯达莫司汀及利妥昔单抗用于治疗复发或难治性弥漫性大B细胞淋巴瘤。
Drugs Today (Barc). 2020 Apr;56(4):287-294. doi: 10.1358/dot.2020.56.4.3127026.
3
Polatuzumab Vedotin: First Global Approval.
泊洛妥珠单抗结合药物:全球首次获批
Drugs. 2019 Sep;79(13):1467-1475. doi: 10.1007/s40265-019-01175-0.
4
Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports.免疫检查点抑制剂治疗患者的噬血细胞性淋巴组织细胞增生症:WHO 个体病例安全报告全球数据库分析。
J Immunother Cancer. 2019 May 2;7(1):117. doi: 10.1186/s40425-019-0598-9.