Zhang Chunyan, Sun Caifang, Zhao Yabin, Ye Bingyu, Yu GuoYing
State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Institute of Biomedical Science, Henan Normal University, Xinxiang, Henan, China.
iScience. 2023 Dec 7;27(1):108683. doi: 10.1016/j.isci.2023.108683. eCollection 2024 Jan 19.
The liver possesses a unique regenerative ability to restore its original mass, in this regard, partial hepatectomy (PHx) and partial liver transplantation (PLTx) can be executed smoothly and safely, which has important implications for the treatment of liver disease. Liver regeneration (LR) can be the very complicated procedure that involves multiple cytokines and transcription factors that interact with each other to activate different signaling pathways. Activation of these pathways can drive the LR process, which can be divided into three stages, namely, the initiation, progression, and termination stages. Therefore, it is important to investigate the pathways involved in LR to elucidate the mechanism of LR. This study reviews the latest research on the key signaling pathways in the different stages of LR.
肝脏具有独特的再生能力，能够恢复其原始质量。在这方面，部分肝切除术（PHx）和部分肝移植（PLTx）可以顺利且安全地进行，这对肝脏疾病的治疗具有重要意义。肝再生（LR）是一个非常复杂的过程，涉及多种细胞因子和转录因子，它们相互作用以激活不同的信号通路。这些通路的激活可以驱动LR过程，该过程可分为三个阶段，即起始、进展和终止阶段。因此，研究参与LR的通路以阐明LR的机制很重要。本研究综述了LR不同阶段关键信号通路的最新研究。
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