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海地一名病态肥胖女性的糖尿病性大疱病。

Bullosis diabeticorum in a morbidly obese woman in Haiti.

作者信息

Paul Axler Jean, Louis Rebecca St, Julien Adonai Aly Isaac, Florvil Frednel, Blaise Wendell

机构信息

General Medicine Department, State University of Haiti, Port-au-Prince, Haiti.

Department of Emergency, University Hospital of Mirebalais, Mirebalais, Haiti.

出版信息

Arch Clin Cases. 2023 Dec 28;10(4):196-199. doi: 10.22551/2023.41.1004.10274. eCollection 2023.

DOI:10.22551/2023.41.1004.10274
PMID:38155997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10754039/
Abstract

Bullosis diabeticorum is a rare skin complication of diabetes mellitus, characterized by sudden onset bullous lesions with no history of trauma. It predominantly affects men and has an acral asymmetric presentation. Here, we report a case of bullous disease in a diabetic patient with morbid obesity, the first described in Haiti. A 40-year-old woman, with a strong history of diabetic for five years, poorly controlled and morbidly obese presented to our emergency for bullosis lesions in her limb. She had a prior presentation about two years ago and, approximately a week before this actual presentation, the same symptomatology occurred suddenly without any trauma. After evaluation and screening, the diagnosis of bullosis diabeticorum was kept. She was initially treated with antibiotics due to signs of superinfection. However, as soon as the symptoms improved, antibiotics were discontinued. An antiseptic lotion and topical antibiotic, neomycin, were used along with daily dressings. About a week after, her blood glucose came to control, signs of infection disappeared as did the bullous lesions and surgical evaluation was performed to ensure proper wound evolution. She was educated by a nutritionist, and our team emphasized the importance of regular follow-up at the hospital. Diabetic bullous disease is very rare and easy to confuse with other diabetic skin complications. A good clinical history is essential to make the diagnosis, and management requires good therapeutic education to avoid the burdensome complications of diabetes.

摘要

糖尿病大疱病是糖尿病一种罕见的皮肤并发症,其特征为突然出现无创伤史的大疱性皮损。该病主要累及男性,呈肢端不对称性表现。在此,我们报告一例海地首例患严重肥胖症的糖尿病患者发生大疱病的病例。一名40岁女性,有5年糖尿病史,病情控制不佳且患有严重肥胖症,因肢体出现大疱病皮损前来我院急诊。她大约两年前曾有过一次发病,在此次实际就诊前约一周,同样的症状突然出现且无任何创伤。经过评估和筛查,确诊为糖尿病大疱病。由于存在超级感染迹象,她最初接受了抗生素治疗。然而,症状一改善,抗生素就停用了。使用了一种消毒洗剂和外用抗生素新霉素,并每日换药。大约一周后,她的血糖得到控制,感染迹象消失,大疱性皮损也消失了,并进行了手术评估以确保伤口正常愈合。一名营养师对她进行了指导,我们的团队强调了在医院定期随访的重要性。糖尿病大疱病非常罕见,容易与其他糖尿病皮肤并发症相混淆。良好的临床病史对于做出诊断至关重要,治疗需要良好的治疗指导以避免糖尿病带来的沉重并发症负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4b/10754039/e9d31d0c2845/acc-10-04-10274-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4b/10754039/5625e45bd78a/acc-10-04-10274-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4b/10754039/e0961fd197b7/acc-10-04-10274-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4b/10754039/e9d31d0c2845/acc-10-04-10274-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4b/10754039/5625e45bd78a/acc-10-04-10274-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4b/10754039/e0961fd197b7/acc-10-04-10274-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a4b/10754039/e9d31d0c2845/acc-10-04-10274-g003.jpg

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as a differential diagnosis for limb ulcers: case report.作为肢体溃疡的鉴别诊断:病例报告
J Vasc Bras. 2022 Sep 9;21:e20210190. doi: 10.1590/1677-5449.202101901. eCollection 2022.
2
Bullous lesions in diabetes mellitus: bullous diabeticorum (diabetic bulla).糖尿病中的大疱性病变:糖尿病大疱(糖尿病性水疱)。
BMJ Case Rep. 2020 Aug 27;13(8):e238617. doi: 10.1136/bcr-2020-238617.
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Recurrent Blister Formation in Setting of Poorly Managed Diabetes Mellitus.糖尿病管理不善情况下的复发性水疱形成
Cureus. 2019 Jun 28;11(6):e5029. doi: 10.7759/cureus.5029.
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Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum.骨髓间充质干细胞移植治疗复发性下肢糖尿病性大疱病患者的疗效及长期纵向随访。
Stem Cell Res Ther. 2018 Apr 10;9(1):99. doi: 10.1186/s13287-018-0854-9.
5
[Bullosis diabeticorum : Two case studies].[糖尿病大疱病:两例病例研究]
Hautarzt. 2018 Sep;69(9):751-755. doi: 10.1007/s00105-018-4132-7.
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Bullosis Diabeticorum: A Rare Presentation with Immunoglobulin G (IgG) Deposition Related Vasculopathy. Case Report and Focused Review.糖尿病大疱病:一种罕见的伴有免疫球蛋白G(IgG)沉积相关血管病变的表现。病例报告及重点综述
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[Diabetic bullose].[糖尿病性大疱]
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Diabetic dermopathy ("shin spots") and diabetic bullae ("bullosis diabeticorum") at the same patient.同一患者身上出现糖尿病性皮肤病(“胫前斑”)和糖尿病大疱(“糖尿病性大疱病”)。
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