Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA; Department of Diagnosis and Surgery, Oral & Maxillofacial Surgery Division, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.
Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA; Department of Diagnosis and Surgery, Periodontics Division, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.
Arch Oral Biol. 2024 Mar;159:105875. doi: 10.1016/j.archoralbio.2023.105875. Epub 2023 Dec 26.
OBJECTIVE: To assess the outcomes of several rodent animal models for studying tooth extraction-related medication-related osteonecrosis of the jaw (MRONJ). DESIGN: After a search of the databases, 2004 articles were located, and 118 corroborated the inclusion factors (in vivo studies in rodents evaluating tooth extraction as a risk factor for the development of MRONJ). RESULTS: Numerous studies attempting to establish an optimal protocol to induce MRONJ were found. Zoledronic acid (ZA) was the most used drug, followed by alendronate (ALN). Even when ZA did not lead to the development of MRONJ, its effect compromised the homeostasis of the bone and soft tissue. The association of other risk factors (dexamethasone, diabetes, and tooth-related inflammatory dental disease) besides tooth extraction also played a role in the development of MRONJ. In addition, studies demonstrated a relationship between cumulative dose and MRONJ. CONCLUSIONS: Both ZA and ALN can lead to MRONJ in rodents when equivalent human doses (in osteoporosis or cancer treatment) are used. Local oral risk factors and tooth-related inflammatory dental disease increase the incidence of MRONJ in a tooth extraction-related rodent model.
目的：评估几种用于研究与拔牙相关的药物相关性颌骨坏死（MRONJ）的啮齿动物模型的结果。
设计：在数据库搜索后，找到了 2004 篇文章，其中 118 篇符合纳入标准（在评估拔牙作为 MRONJ 发展风险因素的啮齿动物体内研究）。
结果：发现了许多试图建立诱导 MRONJ 的最佳方案的研究。唑来膦酸（ZA）是最常用的药物，其次是阿仑膦酸钠（ALN）。即使 ZA 未导致 MRONJ 的发生，其也会影响骨和软组织的内稳态。除拔牙外，其他风险因素（地塞米松、糖尿病和与牙齿相关的炎症性牙科疾病）的联合作用也在 MRONJ 的发生中发挥了作用。此外，研究表明累积剂量与 MRONJ 之间存在关系。
结论：当使用等效的人类剂量（骨质疏松或癌症治疗）时，ZA 和 ALN 均可导致啮齿动物发生 MRONJ。局部口腔风险因素和与牙齿相关的炎症性牙科疾病增加了啮齿动物拔牙相关模型中 MRONJ 的发生率。
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