Monnier A, Roy H, Blackburn J, Bussières J-F
Unité de recherche en pratique pharmaceutique, département de pharmacie, centre hospitalier universitaire Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, H3T 1C5 Montréal, QC, Canada.
Département de pharmacie, unité de recherche en pratique pharmaceutique, centre hospitalier universitaire Sainte-Justine, 3175, chemin de la Côte-Sainte-Catherine, H3T 1C5 Montréal, QC, Canada.
Ann Pharm Fr. 2024 Mar;82(2):318-328. doi: 10.1016/j.pharma.2023.12.012. Epub 2023 Dec 29.
The proper use of antimicrobials is a challenge in healthcare establishments.
Describe the detailed antimicrobial consumption profile in 2021-2022. Describe the annual evolutionary profile of the use of antimicrobials in days of therapy/1000 patient days, antibiotic spectrum index/1000 patients days and according to the proportion of days of therapy administered by parenteral route from 2005-2006 to 2021-2022.
Descriptive and retrospective study. All patients admitted to our mother-child hospital center between April 1, 2005 and March 31, 2022 were included. The study covers the consumption of all antimicrobials through the AWare classification of the World Health Organization and antibiotic spectrum index.
A total of 673.9 days of therapy/1000 patients days was calculated in 2021-2022, i.e. 550.8 for antibiotics, 46.5 for antivirals, 67.9 for antifungals and 8.7 for others. A total of 2436 ASI/1000 patient days was calculated in 2021-2021. According to the AWaRe classification, in 2021-2022, 52.1% (287/551) of days of therapy/1000 patients days referred to the "Access" group, 47.8% (263/551) to the "Watch" group and 0.2% (1/551) to the "Reserve" group.
This study aims to explore the use of antimicrobials in a mother-child hospital center. It puts into perspective a stable or even slightly decreasing use of a selection of antimicrobials and compares favorably with published data. Antibiotic governance is based in particular on the periodic evaluation of consumption. Our study illustrates different approaches to quantify and describe this use.
抗菌药物的合理使用是医疗机构面临的一项挑战。
描述2021 - 2022年详细的抗菌药物消费情况。描述2005 - 2006年至2021 - 2022年期间抗菌药物使用在治疗天数/1000患者日、抗生素谱指数/1000患者日以及按胃肠外途径给药的治疗天数比例方面的年度变化情况。
描述性回顾性研究。纳入2005年4月1日至2022年3月31日期间入住我院母婴中心的所有患者。该研究涵盖通过世界卫生组织的AWaRe分类法统计的所有抗菌药物的消费情况以及抗生素谱指数。
2021 - 2022年计算得出的总治疗天数为673.9天/1000患者日，其中抗生素为550.8天，抗病毒药物为46.5天，抗真菌药物为67.9天，其他为8.7天。2021 - 2021年计算得出的总抗生素谱指数为2436/1000患者日。根据AWaRe分类法，在2021 - 2022年，1000患者日中52.1%（287/551）的治疗天数属于“可及”组，47.8%（263/551）属于“谨慎”组，0.2%（1/551）属于“储备”组。
本研究旨在探索母婴中心抗菌药物的使用情况。它展示了某些抗菌药物的使用稳定甚至略有下降的情况，并且与已发表的数据相比具有优势。抗生素管理尤其基于对消费情况的定期评估。我们的研究阐述了量化和描述这种使用情况的不同方法。
