激素对灌注鸡肝中由山梨醇、木糖醇和甘油生成葡萄糖异生作用的影响及其调控

Hormonal effects and the control of gluconeogenesis from sorbitol, xylitol and glycerol in perfused chicken liver.

作者信息

Niwa H, Yamano T, Sugano T, Harris R A

出版信息

Comp Biochem Physiol B. 1986;85(4):739-45. doi: 10.1016/0305-0491(86)90170-7.

Abstract

Addition of sorbitol or xylitol to perfused chicken liver caused a biphasic increase in the rate of glucose production. The second increase correlated with a decrease in the lactate to pyruvate ratio. Increased glucose production in response to the addition of glycerol was not biphasic. Aminooxyacetate inhibited both the inherent second increase in glucose production and stimulatory effects of alanine and pyruvate. The stimulatory effects of norepinephrine and glucagon on gluconeogenesis from sorbitol decreased in the presence of methylene blue. Only the stimulatory effect of norepinephrine was inhibited by aminooxyacetate.

摘要

向灌注的鸡肝中添加山梨醇或木糖醇会导致葡萄糖生成速率呈双相增加。第二次增加与乳酸与丙酮酸比值的降低相关。添加甘油后葡萄糖生成增加并非双相的。氨氧乙酸既抑制葡萄糖生成固有的第二次增加，也抑制丙氨酸和丙酮酸的刺激作用。在亚甲蓝存在的情况下，去甲肾上腺素和胰高血糖素对山梨醇糖异生的刺激作用减弱。只有去甲肾上腺素的刺激作用被氨氧乙酸抑制。