Department of Surgery, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman.
Department of Cardiothoracic Surgery, National Heart Center, Royal Hospital, Muscat, Oman.
Sultan Qaboos Univ Med J. 2023 Dec;23(Spec Iss):10-15. doi: 10.18295/squmj.12.2023.073. Epub 2023 Nov 30.
There is limited data published from outside North America and Europe comparing the outcomes of a modified Blalock-Taussig shunt (MBTS) and ductal stenting as the first palliative procedure for infants with duct-dependent pulmonary circulation. This study reports the National Heart Center's, in Muscat, Oman, experience in comparing the outcomes of these 2 interventions.
This retrospective study included all infants with duct-dependent pulmonary circulation who received either a MBTS or ductal stenting from 2016-2019. The primary outcomes were death or re-interventions. Secondary outcomes included death, subsequent re-interventions, survival to subsequent surgical intervention, survival to hospital discharge, post-procedural mechanical ventilation and duration of intensive care unit stay.
A total of 71 patients were included in the study, 33 (46%) of whom received ductal stenting. The prevalence of the primary outcome (death or re-intervention) in the patent ductus arteriosus (PDA) stent group was 54.5% versus 31.6% in the MBTS group but this was not statistically significant ( = 0.06). There was no difference between the 2 groups in terms of time to next surgical intervention ( = 0.233). The PDA stent group had shorter post-procedural, mechanical ventilation and intensive care unit stay durations ( <0.05). Syndromic patients were at higher risk of mortality compared to non-syndromic patients.
MBTS and ductal stenting are both acceptable modalities as a palliative intervention for infants with duct-dependant pulmonary circulation. Syndromic patients are at higher risk of mortality. This can be considered an important factor for patient selection.
北美的数据有限,欧洲以外的数据也有限,这些数据比较了改良的 Blalock-Taussig 分流术(MBTS)和导管支架置入术作为依赖导管循环的肺循环婴儿的一线姑息治疗方法的结果。本研究报告了阿曼马斯喀特国家心脏中心在这两种干预方法的结果比较方面的经验。
这项回顾性研究包括所有在 2016 年至 2019 年期间接受 MBTS 或导管支架置入术的依赖导管循环的肺循环婴儿。主要结果是死亡或再次干预。次要结果包括死亡、随后的再次干预、接受后续手术干预的生存、医院出院的生存、术后机械通气和重症监护病房停留时间。
本研究共纳入 71 例患者,其中 33 例(46%)接受了导管支架置入术。在动脉导管未闭(PDA)支架组,主要结局(死亡或再次干预)的发生率为 54.5%,而在 MBTS 组为 31.6%,但差异无统计学意义(=0.06)。两组之间下一次手术干预的时间无差异(=0.233)。PDA 支架组术后机械通气和重症监护病房停留时间较短(<0.05)。综合征患者的死亡率高于非综合征患者。
MBTS 和导管支架置入术都是可接受的姑息治疗方法,适用于依赖导管循环的肺循环婴儿。综合征患者的死亡率较高。这可以被认为是患者选择的一个重要因素。