Pediatric Cardiology unit, Pediatrics' Department, Faculty of Medicine, Cairo University, Egypt.
Research Accessibility Team, Student and Internship research program Faculty of Medicine, Cairo University, Egypt.
Curr Probl Cardiol. 2022 Sep;47(9):100885. doi: 10.1016/j.cpcardiol.2021.100885. Epub 2021 May 8.
In infants with ductal dependent pulmonary blood flow, Blalock-Taussig (BT) shunt and Patent Ductus Arteriosus (PDA) stent, are two palliative procedures aimed to restore circulation. A systematic review and metanalysis was performed on studies comparing PDA stents and BT shunts, in accordance with PRISMA guidelines. Meta-analysis revealed the following; (1) a reduced risk of mortality [RR = 0.585 [0.399-0.859], (P = 0.006)], (2) a reduced risk of complications [RR = 0.523 [0.318-0.860], (P = 0.011), and (3) a reduced risk of ECMO use [R = 0.267 [0.101-0.706] (P = 0.008)], all in the stent group. Additionally, stent group showed higher post procedure oxygen saturation [SMD = 1.307 [95% CI 1.065-1.550], (P < 0.001)], and Nakata index [SMD = 0.679 95% CI [0.513 to 0.845], (P < 0.001)]. PDA stenting presents a viable alternative to BT shunt procedure with better post procedure stability.
在依赖导管的肺血流的婴儿中，Blalock-Taussig（BT）分流术和动脉导管未闭（PDA）支架术是两种旨在恢复循环的姑息性手术。根据 PRISMA 指南，对比较 PDA 支架和 BT 分流术的研究进行了系统评价和荟萃分析。荟萃分析显示：（1）死亡率降低的风险[RR=0.585（0.399-0.859），（P=0.006）]；（2）并发症风险降低的风险[RR=0.523（0.318-0.860），（P=0.011）]；（3）ECMO 使用风险降低的风险[RR=0.267（0.101-0.706），（P=0.008）]，所有这些风险都在支架组中降低。此外，支架组术后氧饱和度更高[SMD=1.307（95%CI 1.065-1.550），（P<0.001）]，Nakata 指数更高[SMD=0.679 95%CI [0.513 至 0.845]，（P<0.001）]。与 BT 分流术相比，PDA 支架术具有更好的术后稳定性，是一种可行的替代方法。
