Chi I C, Waszak C S, Wilkens L R
Contraception. 1986 Nov;34(5):497-503. doi: 10.1016/0010-7824(86)90058-2.
This investigation compares the IUD performance of 372 women who had an insertion-related problem (most with moderate or severe pain) and 372 matched women who had no such problem; all women had interval insertion. A woman in the Problem Cohort and her matched counterpart in the Comparison Cohort were inserted with the same IUD type by the same insertor on the same day or on close dates. The six IUD types used by these women were Lippes Loop D, Copper-7, Copper T-200, Copper T-380 Ag, Multiload Copper 250 and Multiload Copper 375. Cumulative gross life-table rates of the pertinent events (accidental pregnancy, expulsion and medical removal for bleeding and pain), adjusted for age and parity, were calculated. Between the Problem Cohort and the Comparison Cohort, no differences were detected in the event rates that were of either statistical or practical significance. Results from this preliminary study suggest that the insertion-related problems usually encountered during interval insertion such as insertion pain, syncope and/or mild cervical laceration are not associated with an increased risk of IUD discontinuation due to pertinent events.
本研究比较了372名有置入相关问题（大多数有中度或重度疼痛）的女性与372名匹配的无此类问题女性的宫内节育器（IUD）使用情况；所有女性均为间隔期置入。问题队列中的一名女性及其在对照队列中的匹配对象于同一天或相近日期由同一名置入者置入相同类型的IUD。这些女性使用的六种IUD类型分别为Lippes Loop D、铜7、铜T - 200、铜T - 380 Ag、多负载铜250和多负载铜375。计算了经年龄和产次调整后的相关事件（意外妊娠、脱落以及因出血和疼痛而进行的取出）的累积粗寿命表发生率。在问题队列和对照队列之间，未检测到具有统计学或实际意义的事件发生率差异。这项初步研究的结果表明，间隔期置入过程中通常遇到的与置入相关的问题，如置入疼痛、晕厥和/或轻度宫颈裂伤，与因相关事件导致的IUD停用风险增加无关。
