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解读谜题：一例 Tjalma 综合征（假性假性 Meigs' 综合征）伴 CA-125 显著升高和胸腔积液的病例报告。

Deciphering the puzzle: a case report of Tjalma syndrome (pseudo-pseudo Meigs' syndrome) with profoundly elevated CA-125 and pleural effusion.

机构信息

Department of Rheumatology, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.

Department of Cardiology, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.

出版信息

Front Immunol. 2023 Dec 13;14:1277683. doi: 10.3389/fimmu.2023.1277683. eCollection 2023.

DOI:10.3389/fimmu.2023.1277683
PMID:38162662
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10756667/
Abstract

Elevated CA-125 levels, polyserous effusions (such as pleural effusion, ascites, etc.) in young women with systemic lupus erythematosus (SLE) may signal pseudo-pseudo Meigs' syndrome (PPMS), after excluding other causes. We describe a 32-year-old SLE patient with recurrent bilateral pleural effusions and unexplained hypercalcemia for 10 months. Extensive evaluations revealed no infections or tumors. Cytokine analysis showed elevated interleukin (IL) levels, especially IL-6 in pleural effusion. Treatment with immunosuppressive therapy resulted in reduced cancer antigen (CA) 125 levels and decreased effusion volume, demonstrating a positive response to intervention in this case of PPMS.

摘要

CA-125 水平升高，年轻女性全身性红斑狼疮 (SLE) 合并多浆膜腔积液（如胸腔积液、腹水等）时，在排除其他原因后，可能提示假性假性梅格斯综合征 (PPMS)。我们描述了一位 32 岁的 SLE 患者，她反复出现双侧胸腔积液和无法解释的高钙血症 10 个月。广泛的评估未发现感染或肿瘤。细胞因子分析显示白细胞介素 (IL) 水平升高，尤其是胸腔积液中的 IL-6。免疫抑制治疗后，癌抗原 (CA) 125 水平降低，胸腔积液量减少，表明该例 PPMS 对干预有积极反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf1/10756667/d98155ddd627/fimmu-14-1277683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf1/10756667/d98155ddd627/fimmu-14-1277683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf1/10756667/d98155ddd627/fimmu-14-1277683-g001.jpg

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J Autoimmun. 2022 Oct;132:102870. doi: 10.1016/j.jaut.2022.102870. Epub 2022 Jul 22.
2
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Pseudo-Meigs Syndrome Caused by a Giant Uterine Leiomyoma with Cystic Degeneration: A Case Report.
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