Department of Rheumatology, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Department of Cardiology, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Front Immunol. 2023 Dec 13;14:1277683. doi: 10.3389/fimmu.2023.1277683. eCollection 2023.
Elevated CA-125 levels, polyserous effusions (such as pleural effusion, ascites, etc.) in young women with systemic lupus erythematosus (SLE) may signal pseudo-pseudo Meigs' syndrome (PPMS), after excluding other causes. We describe a 32-year-old SLE patient with recurrent bilateral pleural effusions and unexplained hypercalcemia for 10 months. Extensive evaluations revealed no infections or tumors. Cytokine analysis showed elevated interleukin (IL) levels, especially IL-6 in pleural effusion. Treatment with immunosuppressive therapy resulted in reduced cancer antigen (CA) 125 levels and decreased effusion volume, demonstrating a positive response to intervention in this case of PPMS.
CA-125 水平升高，年轻女性全身性红斑狼疮 (SLE) 合并多浆膜腔积液（如胸腔积液、腹水等）时，在排除其他原因后，可能提示假性假性梅格斯综合征 (PPMS)。我们描述了一位 32 岁的 SLE 患者，她反复出现双侧胸腔积液和无法解释的高钙血症 10 个月。广泛的评估未发现感染或肿瘤。细胞因子分析显示白细胞介素 (IL) 水平升高，尤其是胸腔积液中的 IL-6。免疫抑制治疗后，癌抗原 (CA) 125 水平降低，胸腔积液量减少，表明该例 PPMS 对干预有积极反应。
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