Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece; Department of Neurology, 417 Army Equity Fund Hospital (NIMTS), Athens, Greece.
Department of Pharmacology, Medical School, University of Crete & Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas, Heraklion, Crete, Greece.
Mech Ageing Dev. 2024 Feb;217:111899. doi: 10.1016/j.mad.2023.111899. Epub 2023 Dec 30.
Alzheimer's disease (AD) is highly intertwined with sleep disturbances throughout its whole natural history. Sleep consists of a major compound of the functionality of the glymphatic system, as the synchronized slow-wave activity during NREM facilitates cerebrospinal and interstitial long-distance mixing.
The present study undertakes a scoping review of research on the involvement of the glymphatic system in AD-related sleep disturbances.
we searched Medline, Embase, PsychInfo and HEAL-link databases, without limitations on date and language, along with reference lists of relevant reviews and all included studies. We included in vivo, in vitro and post-mortem studies examining glymphatic implications of sleep disturbances in human populations with AD spectrum pathology. A thematic synthesis of evidence based on the extracted content was applied and presented in a narrative way.
In total, 70 original research articles were included and were grouped as following: a) Protein aggregation and toxicity, after sleep deprivation, along with its effects on sleep architecture, b) Glymphatic Sequalae in SDB, yielding potential glymphatic markers c) Circadian Dysregulation, d) Possible Interventions.
this review sought to provide insight into the role of sleep disturbances in AD pathogenesis, in the context of the glymphatic disruption.
阿尔茨海默病（AD）在其整个自然病史中与睡眠障碍高度交织。睡眠由糖质系统功能的主要成分组成，因为在 NREM 期间同步的慢波活动促进了脑脊液和间质的远距离混合。
本研究对糖质系统在 AD 相关睡眠障碍中的作用进行了范围性综述。
我们在 Medline、Embase、PsychInfo 和 HEAL-link 数据库中进行了搜索，没有日期和语言的限制，同时还查阅了相关综述和所有纳入研究的参考文献。我们纳入了在 AD 谱病理人群中检查睡眠障碍对糖质系统影响的体内、体外和死后研究。根据提取的内容应用主题综合证据，并以叙述的方式呈现。
共纳入 70 篇原始研究文章，并分为以下几类：a）睡眠剥夺后蛋白质聚集和毒性及其对睡眠结构的影响，b）睡眠呼吸暂停低通气综合征的糖质系统后果，产生潜在的糖质系统标志物，c）昼夜节律失调，d）可能的干预措施。
本综述旨在深入了解睡眠障碍在 AD 发病机制中的作用，以及糖质系统破坏的情况。
