Al-Ibraheem Akram, Moghrabi Serin, Abdlkadir Ahmed Saad, Haidar Mohamad, Jaber Omar
Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
School of Medicine, The University of Jordan, Amman, Jordan.
Asia Ocean J Nucl Med Biol. 2024;12(1):57-60. doi: 10.22038/AOJNMB.2023.74639.1519.
Tenosynovial giant cell tumors represent a group of typically non-malignant tumors found within the joints and soft tissues. The occurrence of tenosynovial giant cell tumor alongside hematologic malignancies is an infrequent finding. Herein, we report a patient who presented with coinciding Hodgkin Lymphoma (HL) and tenosynovial giant cell tumor before chemotherapy initiation. The case was discovered during initial assessment using [F]fluorodeoxyglucose ([F]FDG) positron emission tomography/computed tomography (PET/CT) imaging for HL staging. An unrelated hypermetabolic mass within the left knee joint led to the discovery of this unusual case, which led to a CT-guided biopsy and tenosynovial giant cell tumor discovery. This was clearly demonstrated in interim and end-of-therapy PET/CT studies when all lymphomatous lesions had resolved but the tenosynovial giant cell tumor remained. This case serves as a reminder of the intricate nature of oncological pathology and emphasizes the need for thorough and vigilant diagnostic evaluation for optimal management plan.
腱鞘巨细胞瘤是一组通常为非恶性的肿瘤，见于关节和软组织内。腱鞘巨细胞瘤与血液系统恶性肿瘤同时出现是一种罕见的情况。在此，我们报告一名患者，在开始化疗前同时患有霍奇金淋巴瘤（HL）和腱鞘巨细胞瘤。该病例是在使用[F]氟脱氧葡萄糖（[F]FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）成像进行HL分期的初始评估期间发现的。左膝关节内一个不相关的高代谢肿块导致了这一罕见病例的发现，进而进行了CT引导下活检并发现了腱鞘巨细胞瘤。在治疗中期和治疗结束时的PET/CT研究中清楚地显示，当所有淋巴瘤病变均已消退但腱鞘巨细胞瘤仍然存在。该病例提醒人们肿瘤病理学的复杂性，并强调为制定最佳管理计划进行全面和警惕的诊断评估的必要性。
