Synthesis of Acrylopimaric Acid Triazole Derivatives and Their Antioomycete Activity against .

To develop new antioomycete agents against plant pathogens, two series of acrylopimaric acid triazole derivatives from rosin were synthesized. The antioomycete activity of these derivatives was evaluated and screened against , , , , and . Compound showed the highest antioomycete activity against , with a half-maximal effective concentration (EC) value that was lower than that of the positive control metalaxyl (1.391 and 1.815 mg/L, respectively). Compound demonstrated satisfactory protective and curative efficacy against in pepper in antioomycete activity studies. Physiological and biochemical testing showed that the action mechanism of compound on involved altering the morphology and ultrastructure of the mycelium, increasing cell membrane permeability, inducing dysfunction of the nucleus and mitochondria, and ultimately causing cell necrosis. In addition, the analysis of three-dimensional quantitative structure-activity relationship (3D-QSAR) revealed the significance of the molecular structure and charge distribution in the interaction between compound and its target. Collectively, these findings indicate that compound has the potential as an antioomycete candidate.