Department of Obstetrics, Nantong Tongzhou People's Hospital, Nantong, China.
Toxicol Mech Methods. 2024 May;34(4):444-453. doi: 10.1080/15376516.2023.2299485. Epub 2024 Jan 2.
Per- and Polyfluoroalkyl Substances (PFAS) are synthetic chemicals utilized in the production of various products that possess water and dirt-repellent properties. Exposure to PFAS has been linked to numerous diseases, such as cancer and preeclampsia (PE). However, whether PFAS contributes to the advancement of PE remains uncertain. In this study, we conducted an extensive bioinformatics analysis using the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) databases, leading us to discover a connection between PE and four specific PFAS. Moreover, further examination revealed that six genes associated with PFAS exhibited significant diagnostic potential for individuals with PE. By employing receiver operating characteristic (ROC) curves, our PFAS-related gene-based nomogram model demonstrated outstanding predictive efficacy for diagnosing PE. Immune infiltration analysis showed that six PFAS-related genes were significantly associated with the level of immune cell infiltration. The expression of PFAS-related genes in PE patients was confirmed by collecting clinical samples. This research has offered fresh perspectives on comprehending the impact of PFAS on PE, drawing attention to the connection between environmental factors and the risks and development of PE.
全氟和多氟烷基物质 (PFAS) 是一种合成化学物质，用于生产具有防水和防污性能的各种产品。接触 PFAS 与许多疾病有关，如癌症和先兆子痫 (PE)。然而，PFAS 是否会导致 PE 的发展尚不确定。在这项研究中，我们使用比较毒理学基因组学数据库 (CTD) 和基因表达综合数据库 (GEO) 进行了广泛的生物信息学分析，发现 PE 与四种特定的 PFAS 之间存在联系。此外，进一步的检查表明，与 PFAS 相关的六个基因对 PE 患者具有显著的诊断潜力。通过使用接收器操作特征 (ROC) 曲线，我们的基于 PFAS 相关基因的列线图模型在诊断 PE 方面表现出出色的预测效果。免疫浸润分析表明，与 PFAS 相关的六个基因与免疫细胞浸润水平显著相关。通过收集临床样本，证实了 PE 患者中 PFAS 相关基因的表达。这项研究为理解 PFAS 对 PE 的影响提供了新的视角，引起了人们对环境因素与 PE 的风险和发展之间联系的关注。
