CYP2B6 基因多态性可能与中国汉族人群的肺癌风险相关。
Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population.
机构信息
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
出版信息
Expert Rev Respir Med. 2023 Dec;17(12):1297-1305. doi: 10.1080/17476348.2024.2302199. Epub 2024 Jan 4.
BACKGROUND
Our study aimed to elucidate the association between single nucleotide polymorphisms (SNPs) in CYP2B6 gene and susceptibility to lung cancer (LC).
METHODS
Five SNPs in CYP2B6 were genotyped in Chinese Han population (507 cases and 505 controls) utilizing Agena MassARRAY. The relationship between these SNPs and LC susceptibility was assessed using odds ratios, 95% confidence intervals, and χ2 tests. Additionally, multifactor dimensionality reduction was employed to analyze SNP-SNP interactions. Bioinformatics methods were applied to investigate the function of these SNPs.
RESULTS
We found that rs2099361 was associated with an increased susceptibility to LC in the codominant model (OR = 1.31, = 0.045). Stratification analysis revealed the allele G at rs4803418 and the allele T at rs4803420 of CYP2B6 (BMI >24 kg/m) were significantly linked to decreased susceptibility of LC. Conversely, the allele C at rs12979270 (BMI >24 kg/m) showed increased susceptibility to LC. Moreover, a robust redundant relationship between rs12979270 and rs4803420 was identified in the study. According to the VannoPortal database, we found that rs4803420, rs12979270 and rs2099361 may modulate the binding affinity of LMNB1, SP1 and HDAC2, respectively.
CONCLUSIONS
Our results suggest that SNPs in the CYP2B6 gene play crucial roles in LC susceptibility.
背景
本研究旨在阐明 CYP2B6 基因单核苷酸多态性（SNPs）与肺癌（LC）易感性之间的关联。
方法
采用 Agena MassARRAY 在中国汉族人群中检测 CYP2B6 中的 5 个 SNPs，并用优势比（OR）、95%置信区间（CI）和卡方检验（χ2检验）评估这些 SNP 与 LC 易感性的关系。此外，还采用多因子降维法分析 SNP-SNP 相互作用。采用生物信息学方法分析这些 SNPs 的功能。
结果
我们发现 rs2099361 在共显性模型中与 LC 易感性增加相关（OR=1.31，P=0.045）。分层分析显示 CYP2B6 的等位基因 G （rs4803418）和等位基因 T （rs4803420）与 BMI>24kg/m2 的 LC 易感性降低显著相关。相反，等位基因 C （rs12979270）与 BMI>24kg/m2 的 LC 易感性增加相关。此外，rs12979270 与 rs4803420 之间存在稳健的冗余关系。根据 VannoPortal 数据库，我们发现 rs4803420、rs12979270 和 rs2099361 可能分别调节 LMNB1、SP1 和 HDAC2 的结合亲和力。
结论
我们的研究结果表明，CYP2B6 基因中的 SNPs 在 LC 易感性中起关键作用。
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