Dihydrophenanthro[]furan derivatives from the tubers of .

Two pairs of new dihydrophenanthro[]furan enantiomers blephebibnols G-H (), one new dihydrophenanthro[]furan derivative blephebibnol I (), along with four known analogues (), were isolated from the tubers of . Their structures including the absolute configurations were determined by the combination of spectroscopic data analysis, ECD and NMR calculations. Compounds , , and showed inhibition of NO production in LPS-stimulated BV-2 cells, with IC values ranging from 4.11 to 14.65 M. Further mechanistic study revealed that suppressed the phosphorylation of p65 subunit to regulate the NF-κB signaling pathway. In addition, some compounds displayed selective cytotoxic activities against HCT-116, HepG2, A549, or HGC27 cancer cell lines with IC values ranging from 0.1 to 8.23 M.