State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, PR China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
Fitoterapia. 2019 Oct;138:104350. doi: 10.1016/j.fitote.2019.104350. Epub 2019 Aug 30.
Three new bibenzyl derivatives (bletstrins A-C, 1-3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilla striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 μg/mL) against S. aureus ATCC 6538.
从白及的块茎中分离得到了三个新的联苄基衍生物（bletstrins A-C，1-3），包括两个具有脂肪族联苄桥手性中心羟基取代的联苄，以及十八个已知的芪类化合物（4-21）。通过使用 1D/2D NMR 光谱数据阐明了新化合物的结构。通过比旋光度确定了 bletitrins A 和 B 的绝对构型。化合物 13-16 是首次从兰科植物中分离得到的。对分离得到的大部分化合物进行了抗菌活性评价，以测试它们对三种革兰氏阳性菌和一种革兰氏阴性菌的抑制作用。化合物 4、10、12、14、15、16 和 18 对金黄色葡萄球菌 ATCC 6538 表现出较强的抑制活性，MIC 值为（6-52μg/mL）。
