药物治疗的癫痫患者血浆和脑脊液中的高香草酸与催乳素

Homovanillic acid and prolactin in plasma and CSF of medicated epileptic patients.

作者信息

Kalfakis N, Markianos M

出版信息

Epilepsia. 1987 Mar-Apr;28(2):138-41. doi: 10.1111/j.1528-1157.1987.tb03639.x.

DOI:10.1111/j.1528-1157.1987.tb03639.x

Abstract

Homovanillic acid (HVA), the main dopamine metabolite, and prolactin (PRL) were estimated in plasma and cerebrospinal fluid (CSF) of 11 male epileptic patients treated with antiepileptic drugs and of 14 neurologic controls. A trend toward higher concentrations in plasma and lower concentrations in CSF in the patient group as compared with controls was observed for both parameters. The plasma to CSF ratios of HVA and PRL levels were significantly higher in the patient group. This shift may be due to an influence of the drugs on the blood-brain barrier (BBB) permeability. The PRL levels in the CSF correlated negatively to the HVA levels in CSF in the patient group only.

摘要

在11名接受抗癫痫药物治疗的男性癫痫患者和14名神经科对照者的血浆和脑脊液（CSF）中，对主要多巴胺代谢物高香草酸（HVA）和催乳素（PRL）进行了评估。与对照组相比，患者组的这两个参数均呈现出血浆浓度较高而脑脊液浓度较低的趋势。患者组中HVA和PRL水平的血浆与脑脊液比率显著更高。这种变化可能是由于药物对血脑屏障（BBB）通透性的影响。仅在患者组中，脑脊液中的PRL水平与脑脊液中的HVA水平呈负相关。