Bourika Vasiliki, Siahanidou Tania, Theodoridou Kalliopi, Tsakris Athanasios, Vrioni Georgia, Michos Athanasios
Neonatal Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece.
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Med Mycol. 2024 Jan 27;62(2). doi: 10.1093/mmy/myad138.
Mannan antigen (MA) in neonates as a marker of invasive candidemia is not well studied, although 4% of all neonatal intensive care unit admissions are attributed to Candida spp. infections. The aim of this case-control study was to evaluate the performance of MA (Platelia™ Candida AgPluskit, Bio-Rad) in neonates who had rectal Candida colonization or in non-colonized controls. We cultured 340 rectal swabs of neonates and MA was negative in 24/25 C. albicans colonized (96% specificity) and in 30/30 non-colonized neonates (100% specificity). The results indicate a high specificity of the assay, which could be useful in neonates with possible candidemia.
尽管新生儿重症监护病房中4%的入院病例归因于念珠菌属感染，但作为侵袭性念珠菌血症标志物的新生儿甘露聚糖抗原（MA）尚未得到充分研究。本病例对照研究的目的是评估MA（Bio-Rad公司的Platelia™念珠菌AgPlus试剂盒）在直肠念珠菌定植的新生儿或未定植的对照新生儿中的表现。我们培养了340份新生儿直肠拭子，在24/25例白色念珠菌定植的新生儿中MA呈阴性（特异性96%），在30/30例未定植的新生儿中MA也呈阴性（特异性100%）。结果表明该检测方法具有高特异性，这可能对疑似念珠菌血症的新生儿有用。
