Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Food Funct. 2024 Jan 22;15(2):894-905. doi: 10.1039/d3fo04366e.
Xylooligosaccharides (XOSs) have recently garnered interest for their potential as an anti-constipation agent. In this study, we investigated the effects of XOSs derived from corn cobs on constipation in mice through a comprehensive analysis of both the metabolome and transcriptome. Our multi-omics approach revealed that XOSs primarily modulated butanoate metabolism and steroid hormone biosynthesis pathways, as well as key signaling pathways such as PPAR and NF-kappa B. Notably, we observed a decrease in inflammatory biomarker expression and an elevation of butyric acid metabolite levels with XOSs treatment. A deeper analysis of gene expression and metabolite alterations highlighted significant changes in genes encoding critical enzymes and metabolites involved in these pathways. Overall, these findings underscore the considerable potential of XOSs derived from corn cobs as a dietary supplement for effectively alleviating constipation.
木低聚糖（XOS）最近因其作为抗便秘剂的潜力而受到关注。在这项研究中，我们通过对代谢组学和转录组学的综合分析，研究了来源于玉米芯的 XOS 对小鼠便秘的影响。我们的多组学方法表明，XOS 主要调节丁酸盐代谢和甾体激素生物合成途径，以及关键的信号通路，如 PPAR 和 NF-κB。值得注意的是，我们观察到 XOS 处理后炎症生物标志物的表达降低，丁酸代谢物水平升高。对基因表达和代谢物变化的深入分析突出了参与这些途径的关键酶和代谢物的编码基因的显著变化。总的来说，这些发现强调了来源于玉米芯的 XOS 作为膳食补充剂有效缓解便秘的巨大潜力。
