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支气管脂肪瘤:一种少见的支气管狭窄或阻塞病因。

Endobronchial Lipoma: A Rare Cause of Bronchial Stenosis or Obstruction.

机构信息

Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi, China.

Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, China.

出版信息

Can Respir J. 2023 Dec 26;2023:2799436. doi: 10.1155/2023/2799436. eCollection 2023.

Abstract

Endobronchial lipoma (EL) is a rare benign tumor characterized by tracheobronchial smooth-surfaced mass, often resulting in bronchial obstruction without standard guidelines for management. This study seeks to clarify the clinical features and interventions of EL, aiming to improve its diagnosis and outcomes. A retrospective review was conducted on 28516 outpatients treated between January 2015 and December 2019 at the Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital of Air Force Medical University to collect patients diagnosed with EL. Their clinical, bronchoscopic, chest imaging, and histopathological features along with management were analyzed. Among the patients reviewed, nine were histopathologically diagnosed with EL, comprising seven males and two females. All EL patients exhibited noticeable symptoms, including cough (in eight patients), dyspnea (in six patients), fever (in three patients), expectoration (in two patients), chest pain (in two patients), hemoptysis (in one patient), and fatigue (in one patient). Chest CT abnormalities included endobronchial mass (in four patients), inflammatory exudation (in three patients), atelectasis (in three patients), and infiltration or consolidation (in two patients). In three patients, imaging showed fat density, directly leading to the diagnosis of EL. The EL lesions were distributed with six in the right lung and three in the left lung, all located within the first three subdivisions of the tracheobronchial tree. Treatment approaches varied, with one patient undergoing combined bronchoscopic resection and surgery. The remaining patients received bronchoscopic intervention such as electrosurgical snare resection, argon plasma coagulation (APC), cryotherapy, and holmium laser. Histopathological analysis confirmed the EL diagnosis. Finally, the mass removal restored bronchus patency. Taken together, EL symptoms lack specificity, necessitating reliance on histopathology for EL accurate diagnosis. Bronchoscopic interventions emerge as the preferred option for EL management, surpassing surgical approaches.

摘要

支气管脂肪瘤(EL)是一种罕见的良性肿瘤,其特征为气管支气管表面光滑的肿块,常导致支气管阻塞,但目前尚无管理的标准指南。本研究旨在阐明 EL 的临床特征和干预措施,以改善其诊断和预后。回顾性分析了 2015 年 1 月至 2019 年 12 月在空军军医大学第二附属医院呼吸与危重症医学科就诊的 28516 例门诊患者,收集诊断为 EL 的患者。分析了他们的临床、支气管镜、胸部影像学和组织病理学特征以及治疗方法。在回顾的患者中,有 9 例组织病理学诊断为 EL,包括 7 名男性和 2 名女性。所有 EL 患者均出现明显症状,包括咳嗽(8 例)、呼吸困难(6 例)、发热(3 例)、咳痰(2 例)、胸痛(2 例)、咯血(1 例)和乏力(1 例)。胸部 CT 异常包括支气管内肿块(4 例)、炎性渗出(3 例)、肺不张(3 例)和浸润或实变(2 例)。在 3 例患者中,影像学显示脂肪密度,直接导致 EL 的诊断。EL 病变分布在右肺 6 例,左肺 3 例,均位于气管支气管树的前三个分支内。治疗方法各异,1 例患者行支气管镜下联合切除和手术治疗。其余患者行支气管镜介入治疗,如电圈套切除术、氩等离子凝固术(APC)、冷冻治疗和钬激光治疗。组织病理学分析证实了 EL 的诊断。最后,肿块切除恢复了支气管通畅。总之,EL 症状缺乏特异性,需要依靠组织病理学明确 EL 诊断。支气管镜介入治疗是 EL 治疗的首选方法,优于手术方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6038/10761223/e839dab14fe0/CRJ2023-2799436.001.jpg

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