腮腺淋巴结转移对腮腺癌远处转移的影响。
Influence of parotid lymph node metastasis on distant metastasis in parotid gland cancer.
作者信息
Meng Fan, Yuan Junhui, Zhang Xu, Liu Jun, Li Hailiang
机构信息
Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.
Department of Head and Neck, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.
出版信息
Front Oncol. 2023 Dec 18;13:1244194. doi: 10.3389/fonc.2023.1244194. eCollection 2023.
BACKGROUND
The aim of this study was to analyze the impact of the number and extranodal extension (ENE) of positive parotid lymph nodes (LNs) on distant metastasis in parotid cancer.
METHODS
Patients with surgically treated parotid cancer were retrospectively enrolled. The hazard ratios (HRs) of the number and ENE of positive parotid LNs on distant metastasis-free survival (DMFS) were evaluated.
RESULTS
In the Cox model, the groups with zero and one positive LN had comparable 10-year DMFS, but those with two positive LNs had an HR of 2.11 (95% CI: 1.36-5.29), and those with three or more positive LNs had an HR of 3.31 (95% CI: 2.05-8.43). The presence of ENE in parotid LNs did not impact the DMFS ( = 0.462; HR: 2.17; 95% CI: 0.84-6.17).
CONCLUSION
Parotid LN metastasis was associated with decreased DMFS; this effect was mainly driven by the number of positive LNs rather than ENE.
背景
本研究旨在分析腮腺癌中阳性腮腺淋巴结（LN）的数量及结外侵犯（ENE）对远处转移的影响。
方法
回顾性纳入接受手术治疗的腮腺癌患者。评估阳性腮腺LN的数量及ENE对无远处转移生存期（DMFS）的风险比（HR）。
结果
在Cox模型中，零个和一个阳性LN的组10年DMFS相当，但两个阳性LN的组HR为2.11（95%CI：1.36 - 5.29），三个或更多阳性LN的组HR为3.31（95%CI：2.05 - 8.43）。腮腺LN中ENE的存在不影响DMFS（P = 0.462；HR：2.17；95%CI：0.84 - 6.17）。
结论
腮腺LN转移与DMFS降低相关；这种影响主要由阳性LN的数量而非ENE驱动。
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