Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Shanghai, China.
Head Neck. 2022 Dec;44(12):2660-2667. doi: 10.1002/hed.27173. Epub 2022 Aug 24.
To evaluate the predicting factors associated with distant metastasis (DM) for lymphoepithelial carcinoma of salivary gland (LECSG) following postoperative radiotherapy (PORT).
We retrospectively collected 160 eligible patients from two cancer institutions. The DM rate was evaluated using competing risk method.
The median follow-up time was 65.6 months. Elevated preradiotherapy serum LDH (ratio >0.5) (p = 0.006) and N classification (N2-3) (p = 0.001) were independently associated with DM for the LECSG. After the risk stratification, the high-risk subgroup was defined as the patients presented higher risk score (score >0), whereas 5-year cumulative incidence of DM in the high- and low-risk group was 30.9% and 6.0%, respectively (p < 0.001). Moreover, a significantly worse overall survival (OS) was observed in the high-risk patients compared with the low-risk subgroup (5-year OS: 83.9% vs. 97.8%, p = 0.006).
Elevated preradiotherapy serum LDH could serve as a predictive factor for DM in the LECSG following PORT.
评估接受术后放疗（PORT）的涎腺淋巴上皮癌（LECSG）远处转移（DM）相关的预测因素。
我们从两家癌症机构回顾性收集了 160 名合格患者。使用竞争风险方法评估 DM 率。
中位随访时间为 65.6 个月。放疗前血清乳酸脱氢酶（LDH）升高（比值>0.5）（p=0.006）和 N 分类（N2-3）（p=0.001）与 LECSG 的 DM 独立相关。在风险分层后，高风险亚组定义为具有较高风险评分（评分>0）的患者，而高、低风险组 5 年 DM 的累积发生率分别为 30.9%和 6.0%（p<0.001）。此外，与低风险亚组相比，高风险患者的总生存率（OS）明显更差（5 年 OS：83.9% vs. 97.8%，p=0.006）。
放疗前血清 LDH 升高可作为 PORT 后 LECSG 中 DM 的预测因素。
