Department of Pediatric General Surgery, Yongchuan Maternal and Child Health Hospital, Chongqing, People's Republic of China.
Department of Pediatric General Surgery, Chongqing Health Center for Women and Children, Chongqing Medical University, Chongqing, People's Republic of China.
Sci Rep. 2024 Jan 3;14(1):457. doi: 10.1038/s41598-023-50493-7.
The optimal treatment for acute intussusception has not yet been defined. In this study, we explored whether employing a liberal laparoscopic intervention for intussusception could lead to favorable outcomes. We performed a historical control analysis to evaluate the outcomes associated with this liberal surgical management protocol. This liberal surgical management protocol were revised to incorporate a new protocol centered around the laparoscopic approach. In some cases of acute intussusception, liberal laparoscopic exploration and intervention were undertaken without initial hydrostatic or pneumatic reduction. During the study interval, a retrospective review was conducted on a total of 3086 patients. These were categorized into two groups: 1338 cases before May 2019 (pre-protocol group) and 1748 cases after May 2019 (post-protocol group). Surgical intervention rates in the pre-protoco and post-protocol period were 10.2% and 27.4% respectively (odds ratio [OR] = 0.30 [95% CI 0.25-0.37]; p < 0.001). No significant differences were observed in baseline clinical characteristics or demographic features between the two groups. The duration from admission to operation was longer for the pre-protocol group (p = 0.008) than for the post-protocol group. The post-protocol group demonstrated decreases in both intestinal resection (OR = 1.50 [95% CI 0.96-2.35]; p = 0.048) and total recurrent events (OR = 1.27 [95% CI 1.04-1.55]; p = 0.012) compared to the pre-protocol group. Liberal laparoscopic intervention for intussusception may effectively reduce the risk of intestinal resection and total recurrent events, thereby exhibiting promising outcomes for patients with intussusception.
急性肠套叠的最佳治疗方法尚未确定。在本研究中,我们探讨了采用自由腹腔镜干预肠套叠是否能带来良好的结果。我们进行了历史对照分析,以评估与这种自由手术管理方案相关的结果。对这种自由手术管理方案进行了修订,纳入了以腹腔镜方法为中心的新方案。在一些急性肠套叠病例中,在没有初始水压或气压复位的情况下,进行了自由腹腔镜探查和干预。在研究期间,对总共 3086 名患者进行了回顾性分析。这些患者分为两组:1999 年 5 月前(方案前组)的 1338 例和 1999 年 5 月后(方案后组)的 1748 例。方案前和方案后时期的手术干预率分别为 10.2%和 27.4%(比值比 [OR] = 0.30 [95% CI 0.25-0.37];p < 0.001)。两组患者的基线临床特征或人口统计学特征无显著差异。方案前组患者从入院到手术的时间较长(p = 0.008)。与方案前组相比,方案后组肠切除(OR = 1.50 [95% CI 0.96-2.35];p = 0.048)和总复发事件(OR = 1.27 [95% CI 1.04-1.55];p = 0.012)的发生率均降低。自由腹腔镜干预肠套叠可能有效降低肠切除和总复发事件的风险,从而为肠套叠患者带来良好的预后。