rs641738基因多态性与肝细胞癌易感性的关联：一项系统评价和荟萃分析。
Association of rs641738 polymorphism with hepatocellular carcinoma susceptibility: A systematic review and meta-analysis.
作者信息
Lai Min, Qin Ya-Lu, Jin Qiong-Yu, Chen Wen-Jing, Hu Jia
机构信息
Department of Gastroenterology, the Third Affiliated Hospital of Chengdu Medical College/Chengdu Pidu District People's Hospital, Chengdu 611730, Sichuan Province, China.
Department of Cardiology, the Affiliated Third Hospital of Chengdu Traditional Chinese Medicine University/Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu 611730, Sichuan Province, China.
出版信息
World J Gastrointest Oncol. 2023 Dec 15;15(12):2225-2236. doi: 10.4251/wjgo.v15.i12.2225.
BACKGROUND
The rs641738 single-nucleotide polymorphism (SNP) has been proven to influence various liver diseases, but its association with hepatocellular carcinoma (HCC) susceptibility has been debated. To address this discrepancy, we conducted the current systematic review and meta-analysis.
AIM
To perform a systematic review and meta-analysis on association of SNP and HCC susceptibility.
METHODS
We performed a systematic review in PubMed, Web of Science, Scopus, and EMBASE; applied specific inclusion and exclusion criteria; and extracted the data. Meta-analysis was conducted with the package in R. Sensitivity and subgroup analyses were also performed. This meta-analysis was registered in PROSPERO (CRD42023458046).
RESULTS
Eight studies were included in the systematic review, and 12 cohorts from 6 studies were included in the meta-analysis. Our meta-analysis revealed an association between the SNP and HCC susceptibility in both the dominant [odds ratio (OR): 1.14, 95% confidence interval (95%CI): 1.02-1.26, = 0.020] and recessive (OR: 1.21, 95%CI: 1.05-1.39, = 0.008) models. Subgroup analysis revealed that stratification of the included patients by geographical origin showed a significant association in Asia (OR: 1.20, 95%CI: 1.03-1.39).
CONCLUSION
This meta-analysis underscores the contribution of the rs641738 SNP to hepatocarcinogenesis, especially in Asian populations, which warrants further investigation.
背景
rs641738单核苷酸多态性（SNP）已被证明会影响多种肝脏疾病，但其与肝细胞癌（HCC）易感性的关联一直存在争议。为了解决这一差异，我们进行了本次系统评价和荟萃分析。
目的
对SNP与HCC易感性的关联进行系统评价和荟萃分析。
方法
我们在PubMed、Web of Science、Scopus和EMBASE中进行了系统评价；应用了特定的纳入和排除标准；并提取了数据。使用R软件包进行荟萃分析。还进行了敏感性和亚组分析。该荟萃分析已在PROSPERO（CRD42023458046）中注册。
结果
系统评价纳入了8项研究，荟萃分析纳入了6项研究中的12个队列。我们的荟萃分析显示，在显性模型[比值比（OR）：1.14，95%置信区间（95%CI）：1.02-1.26，P = 0.020]和隐性模型（OR：1.21，95%CI：1.05-1.39，P = 0.008）中，该SNP与HCC易感性之间均存在关联。亚组分析显示，按地理来源对纳入患者进行分层后，在亚洲显示出显著关联（OR：1.20，95%CI：1.03-1.39）。
结论
该荟萃分析强调了rs641738 SNP对肝癌发生的作用，尤其是在亚洲人群中，这值得进一步研究。
Zotero 插件