Department of Ultrasound, The People's Hospital of Danyang, Danyang Hospital of Nantong University, Danyang, China.
Department of Endocrinology, The People's Hospital of Danyang, Danyang Hospital of Nantong University, Danyang, China.
Front Endocrinol (Lausanne). 2023 Dec 19;14:1279570. doi: 10.3389/fendo.2023.1279570. eCollection 2023.
To evaluate left ventricular (LV) function in patients with subclinical hypothyroidism (ScH) compared to healthy individuals and to provide clinical hints for practitioners.
PubMed, Embase, Cochrane Library, and Web of Science were systematically searched in this meta-analysis. Studies evaluating LV function in ScH patients were included. Standardized mean difference (SMD) and the 95% confidence intervals (CIs) were calculated as effect size. Heterogeneity and risks of bias of included studies were assessed.
A total of 9 studies were identified as eligible. The SMD for fractional shortening (FS, %) was -0.21 (95% CI: -0.60, 0.17; z = -1.08, p = 0.2788). The pooled SMD for systemic vascular resistance (SVR, dynes/sec·cm-5) was -0.41 (95% CI: -1.31, 0.49; z = -0.89, p = 0.3744). The pooled SMD for early diastolic mitral flow velocity/late diastolic mitral flow velocity (E/A) ratio was -0.74 (95% CI: -1.09, -0.39; z = -4.13, p < 0.001). The pooled SMD for ejection fraction (EF, %) was -0.35 (95% CI: -0.59, -0.12; z = -2.95, p = 0.0032).
ScH patients had significantly worse LV function parameters than healthy controls. These changes in LV function may be involved in the management of ScH.
评估亚临床甲状腺功能减退症（ScH）患者的左心室（LV）功能与健康个体相比的情况，并为临床医生提供临床提示。
本荟萃分析系统地检索了 PubMed、Embase、Cochrane 图书馆和 Web of Science。纳入评估 ScH 患者 LV 功能的研究。计算标准化均数差（SMD）和 95%置信区间（CI）作为效应量。评估纳入研究的异质性和偏倚风险。
共确定了 9 项符合条件的研究。分数缩短率（FS，%）的 SMD 为-0.21（95%CI：-0.60，0.17；z=-1.08，p=0.2788）。系统性血管阻力（SVR，dynes/sec·cm-5）的合并 SMD 为-0.41（95%CI：-1.31，0.49；z=-0.89，p=0.3744）。早期舒张二尖瓣血流速度/晚期舒张二尖瓣血流速度（E/A）比值的合并 SMD 为-0.74（95%CI：-1.09，-0.39；z=-4.13，p<0.001）。射血分数（EF，%）的合并 SMD 为-0.35（95%CI：-0.59，-0.12；z=-2.95，p=0.0032）。
ScH 患者的 LV 功能参数明显差于健康对照组。LV 功能的这些变化可能涉及 ScH 的管理。
