The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Folia Neuropathol. 2024;62(2):136-146. doi: 10.5114/fn.2023.132329.
The role of functional magnetic resonance imaging (fMRI) findings in investigation of working memory (WM) deficit in schizophrenia patients is still debatable. The aim of the study was to investigate the role of fMRI findings of the frontal and parietal brain activity in investigation of WM deficit in schizophrenia patients.
We used Medline, Embase, and the Cochrane Database to conduct a comprehensive search up to January 2023. Functional MRI findings of schizophrenia patients were compared with healthy patients in comparative studies for assessing their WM capacity in terms of dorsolateral prefrontal cortex and parietal region activation. The Cochrane Risk of Bias Assessment Tool was used to evaluate the research quality.
Ten trials and 676 schizophrenia patients were included in our analysis. For the comparative assessment of primary outcome - alteration in dorsolateral prefrontal cortex and parietal region activity in schizophrenic patients versus healthy controls - we found the pooled odds ratio (OR) of 1.58 [95% CI: 1.09-2.29], I 2 = 61% and p = 0.01 and risk ratio (RR) was 1.27 [95% CI: 1.06-1.53], I 2 = 55% and p = 0.01. The AUC value of 0.944 indicates a favourable overall diagnostic performance of fMRI for the diagnosis of schizophrenia.
fMRI findings showing abnormalities in the parietal and frontal regions can be used to study schizophrenia patients' WM deficits.
功能磁共振成像（fMRI）在研究精神分裂症患者工作记忆（WM）缺陷中的作用仍存在争议。本研究旨在探讨额顶叶脑区活动的 fMRI 发现对精神分裂症患者 WM 缺陷的研究作用。
我们使用 Medline、Embase 和 Cochrane 数据库进行了全面检索，截至 2023 年 1 月。在比较研究中，我们比较了精神分裂症患者的 fMRI 发现与健康患者的 fMRI 发现，以评估他们在背外侧前额叶皮质和顶叶区域激活方面的 WM 能力。我们使用 Cochrane 偏倚风险评估工具来评估研究质量。
我们的分析纳入了 10 项试验和 676 名精神分裂症患者。对于主要结局——精神分裂症患者与健康对照组之间背外侧前额叶皮质和顶叶区域活动的改变——的比较评估，我们发现合并优势比（OR）为 1.58 [95% CI：1.09-2.29]，I 2 = 61%，p = 0.01，风险比（RR）为 1.27 [95% CI：1.06-1.53]，I 2 = 55%，p = 0.01。AUC 值为 0.944，表明 fMRI 对精神分裂症的诊断具有良好的整体诊断性能。
fMRI 发现额顶叶区域存在异常，可以用于研究精神分裂症患者的 WM 缺陷。
