School of Biological and Pharmaceutical Sciences, Shaanxi University of Science and Technology, Xi'an 710021, PR China.
School of Biological and Pharmaceutical Sciences, Shaanxi University of Science and Technology, Xi'an 710021, PR China.
J Mech Behav Biomed Mater. 2024 Mar;151:106355. doi: 10.1016/j.jmbbm.2023.106355. Epub 2023 Dec 29.
In recent years, electroactive nerve conduits made from a blend of P(VDF-TrFE) (poly (vinylidene fluoride-trifluoroethylene)) with other materials have shown significant progress. However, research combining P(VDF-TrFE) conduits with drug delivery systems remains sparse. In this study, we developed a novel gastrodin-loaded P(VDF-TrFE)-Eudragit L100-gold nanoparticles (Gas@PT-EL100-AuNPs) nanofiber membrane. Fabricated through electrospinning technique, this composite membrane aimed to investigate the impacts of gastrodin and AuNPs on its properties. Experimental results indicated that the incorporation of gold nanoparticles significantly reduced the fiber diameter of the membrane and enhanced the overall performance by improving hydrophilicity and piezoelectric properties. Specifically, the addition of AuNPs substantially enhanced the piezoelectric performance of the nanofiber membrane. Furthermore, the inclusion of gastrodin not only improved the membrane's hydrophilicity but also enabled effective release of the neuroprotective drug. These findings suggest that the Gas@PT-EL100-AuNPs nanofiber membrane is a novel biomaterial with potential applications in the repair and treatment of nerve injuries.
近年来，由聚偏氟乙烯-三氟乙烯（P(VDF-TrFE))与其他材料混合制成的电活性神经导管取得了显著进展。然而，将 P(VDF-TrFE)导管与药物输送系统相结合的研究仍然很少。在这项研究中，我们开发了一种新型天麻素负载的 P(VDF-TrFE)-Eudragit L100-金纳米粒子（Gas@PT-EL100-AuNPs）纳米纤维膜。通过静电纺丝技术制备的这种复合膜旨在研究天麻素和 AuNPs 对其性能的影响。实验结果表明，金纳米粒子的掺入显著降低了膜的纤维直径，并通过提高亲水性和压电性能来增强整体性能。具体来说，AuNPs 的加入极大地提高了纳米纤维膜的压电性能。此外，天麻素的加入不仅提高了膜的亲水性，而且还实现了神经保护药物的有效释放。这些发现表明，Gas@PT-EL100-AuNPs 纳米纤维膜是一种具有潜在应用前景的新型生物材料，可用于神经损伤的修复和治疗。
