左旋多巴治疗儿童肌张力障碍：病例系列及文献复习。
Levodopa for Dystonia in Children: A Case Series and Review of the Literature.
机构信息
Department of Pediatrics, Yale University, New Haven, Connecticut; Department of Neurology, Yale University, New Haven, Connecticut.
Department of Pediatrics, Yale University, New Haven, Connecticut; Department of Neurology, Yale University, New Haven, Connecticut; Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut; Wu Tsai Institute, Yale University, New Haven, Connecticut; Department of Neurology, University of Washington, Seattle, Washington.
出版信息
Pediatr Neurol. 2024 Mar;152:16-19. doi: 10.1016/j.pediatrneurol.2023.12.012. Epub 2023 Dec 19.
BACKGROUND
Levodopa is used to treat hyperkinetic movements in children with dopa-responsive dystonia. However, levodopa may also be helpful in treating other forms of dystonia when used beyond a brief trial period.
METHODS
We performed a retrospective review of all children referred to our institution for evaluation of generalized dystonia and subsequently treated with carbidopa-levodopa. Motor function was assessed using video recordings and examination notes, quantified with the Burke-Fahn-Marsden Dystonia Rating Scale.
RESULTS
Long-term treatment with carbidopa-levodopa moderately improved motor function, whereas short-term use did not. Carbidopa-levodopa was well tolerated without untoward effects.
CONCLUSIONS
Dystonia is a significant cause of disability with limited effective treatment options. Published work is restricted but generally supports the findings of this review. A well-controlled study to examine the utility of carbidopa-levodopa treatment for dystonia is needed.
背景
左旋多巴用于治疗多巴反应性肌张力障碍儿童的多动运动。然而，当使用时间超过短暂的试验期时，左旋多巴在治疗其他形式的肌张力障碍时也可能有帮助。
方法
我们对所有因全身性肌张力障碍而转至我们机构评估并随后接受卡比多巴-左旋多巴治疗的儿童进行了回顾性研究。使用视频记录和检查记录评估运动功能，并使用 Burke-Fahn-Marsden 肌张力障碍评定量表进行量化。
结果
长期使用卡比多巴-左旋多巴可适度改善运动功能，而短期使用则不能。卡比多巴-左旋多巴耐受性良好，无不良反应。
结论
肌张力障碍是一种严重的致残性疾病，治疗方法有限。已发表的研究工作受到限制，但通常支持本综述的研究结果。需要进行一项精心控制的研究，以检验卡比多巴-左旋多巴治疗肌张力障碍的效用。
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