异甜菊醇在过去 15 年的生物活性和结构修饰。

Biological activity and structural modification of isosteviol over the past 15 years.

机构信息

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China.

出版信息

Bioorg Chem. 2024 Feb;143:107074. doi: 10.1016/j.bioorg.2023.107074. Epub 2023 Dec 31.

DOI:10.1016/j.bioorg.2023.107074

Abstract

Isosteviol is a tetracyclic diterpenoid obtained by hydrolysis of stevioside. Due to its unique molecular skeleton and extensive pharmacological activities, isosteviol has attracted more and more attention from researchers. This review summarized the structural modification, pharmacological activity and microbial transformation of isosteviol from 04/2008 to 10/2023. In addition, the research history, structural characterization, and pharmacokinetics of isosteviol were also briefly reviewed. This review aims to provide useful literature resources and inspirations for the exploration of diterpenoid drugs.

摘要

异甜菊醇是甜菊醇经水解得到的四环二萜。由于其独特的分子骨架和广泛的药理活性，异甜菊醇越来越受到研究人员的关注。本文综述了 2008 年 4 月至 2023 年 10 月期间异甜菊醇的结构修饰、药理活性和微生物转化研究进展。此外，还简要回顾了异甜菊醇的研究历史、结构特征和药代动力学。本文旨在为二萜类药物的探索提供有用的文献资源和启示。