Gerok W
Klin Wochenschr. 1979 Jun 15;57(12):613-23. doi: 10.1007/BF01477628.
The following pathogenetic mechanisms, exemplified by three diseases (diabetes mellitus, hyperthyroidism and familial hypercholesterolemia), are discussed: 1. The impaired interaction between a chemical signal and a specific receptor can be the cause of a disease. 2. The cause for an imparied interaction can be a defect of the receptor, i.e., a reduced number of receptors or an altered receptor affinity, or a wrong signal. 3. A defect of the receptor can be induced by exogenous influences or it can be determined genetically. 4. The receptor and the signal can be modified by their interaction: the number of receptors is reduced by high concentrations of the chemical signal or by increased degradation due to binding to the receptor. 5. The receptor concept opens new perspectives for the pathogenetic understanding, diagnosis and therapy of some diseases.
以下以三种疾病（糖尿病、甲状腺功能亢进和家族性高胆固醇血症）为例，讨论了以下发病机制：1. 化学信号与特定受体之间的相互作用受损可能是疾病的原因。2. 相互作用受损的原因可能是受体缺陷，即受体数量减少或受体亲和力改变，或者是错误的信号。3. 受体缺陷可由外源性影响诱发，也可由遗传决定。4. 受体和信号可通过它们的相互作用而改变：化学信号的高浓度或由于与受体结合导致的降解增加会使受体数量减少。5. 受体概念为某些疾病的发病机制理解、诊断和治疗开辟了新的视角。
