兔 mRNA 疫苗接种改变了成年印鼠客蚤的繁殖力，但不影响其附着。
mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis.
机构信息
Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, 06520, USA.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
出版信息
Sci Rep. 2024 Jan 4;14(1):496. doi: 10.1038/s41598-023-50389-6.
19ISP is a nucleoside-modified mRNA-lipid nanoparticle vaccine that targets 19 Ixodes scapularis proteins. We demonstrate that adult I. scapularis have impaired fecundity when allowed to engorge on 19ISP-immunized rabbits. 19ISP, therefore, has the potential to interrupt the tick reproductive cycle, without triggering some of the other effects associated with acquired tick resistance. This may lead to the development of new strategies to reduce I. scapularis populations in endemic areas.
19ISP 是一种核苷修饰的 mRNA-脂质纳米颗粒疫苗，针对 19 种硬蜱蛋白。我们证明，当让 19ISP 免疫的兔子饱食时，硬蜱的成虫繁殖力受损。因此，19ISP 有可能中断蜱的生殖周期，而不会引发与获得性蜱抗性相关的一些其他影响。这可能会导致开发新策略来减少流行地区的硬蜱种群。
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