Department of Pharmacy, Zhongshan Hospital (Xiamen), Fudan University, 361015 Xiamen, Fujian, China; Department of Pharmacy, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.
Nursing Department, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.
Heart Surg Forum. 2023 Dec 7;26(6):E680-E686. doi: 10.59958/hsf.6937.
To investigate the correlation between mean platelet volume (MPV) levels and Gensini scores in stable coronary heart disease (CHD) patients with or without diabetes.
A retrospective analysis was conducted on 2525 patients with stable CHD in Zhongshan Hospital, Fudan University. There were 1274 in the low MPV group and 1251 in the high MPV group, divided by a median MPV level of 10.9 fL. In the total population, 1605 patients were non-diabetic and 920 were diabetic. The severity of coronary artery disease was quantified using the Gensini score.
The Gensini score was significantly higher in the high MPV group than in the low MPV group (p < 0.001). MPV levels increased significantly with the number of stenotic (>50%) coronary vessels (p < 0.001). The Spearman analysis showed a positive correlation between MPV and Gensini score (r = 0.189, p < 0.001), which was more significant in the diabetic subgroup (r = 0.232, p < 0.001). Receiver operating characteristic (ROC) curves were employed to assess the predictive value of MPV for high Gensini scores, using the median value of 32 points as the cutoff. MPV levels in the diabetes cohort exhibited a higher predictive value for high Gensini scores (area under the curve: 0.635 [0.614-0.657], p < 0.001). Multivariate linear regression analysis showed that diabetes and MPV were independently associated with Gensini scores.
MPV levels in stable CHD patients can predict the severity of coronary artery stenosis. This correlation is more significant in the presence of diabetes.
探讨合并或不合并糖尿病的稳定性冠心病患者血小板平均体积（MPV）水平与 Gensini 评分的相关性。
对复旦大学中山医院 2525 例稳定性冠心病患者进行回顾性分析。根据 MPV 中位数 10.9fL 将患者分为低 MPV 组（n=1274）和高 MPV 组（n=1251）。在总人群中，1605 例患者为非糖尿病患者，920 例患者为糖尿病患者。采用 Gensini 评分量化冠状动脉疾病严重程度。
高 MPV 组的 Gensini 评分明显高于低 MPV 组（p＜0.001）。MPV 水平随狭窄（＞50%）冠状动脉数量的增加而显著升高（p＜0.001）。Spearman 分析显示 MPV 与 Gensini 评分呈正相关（r=0.189，p＜0.001），在糖尿病亚组中更为显著（r=0.232，p＜0.001）。采用中位数 32 分作为截断值，绘制受试者工作特征（ROC）曲线评估 MPV 对高 Gensini 评分的预测价值。糖尿病组 MPV 水平对高 Gensini 评分的预测价值更高（曲线下面积：0.635[0.614-0.657]，p＜0.001）。多变量线性回归分析显示，糖尿病和 MPV 与 Gensini 评分独立相关。
稳定性冠心病患者的 MPV 水平可预测冠状动脉狭窄严重程度，且在合并糖尿病时相关性更为显著。
