Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, 100853, China.
Curr Pharm Biotechnol. 2024;25(14):1807-1817. doi: 10.2174/0113892010261032231214115415.
Protein/peptide drugs are extensively used to treat various chronic and serious diseases. The short half-life of protein and peptide as therapeutics drug limit the realization of complete effects. Encapsulating drugs in microspheres can slow the speed of drug release and prolong the efficacy of drugs. The solvent evaporation method is widely used to prepare protein/ peptide microspheres because of its facile operation and minimal equipment requirements. This method has several challenges in the lower encapsulation efficiency, fluctuant release profiles and the stabilization of protein/peptides, which researchers believe may be solved by adjusting the preparation parameter or formulation of microspheres. The article discusses the formulation parameters that govern the preparation of protein/peptide-loaded microspheres by the solvent evaporation method, which provides an overview of the current promising strategies for solvent evaporation for protein/peptide microspheres. The article takes parameter evaluation as the framework, facilitating subsequent researchers to quickly find possible solutions when encountering problems.
蛋白质/肽类药物被广泛用于治疗各种慢性和严重疾病。作为治疗药物的蛋白质和肽类的半衰期短，限制了其完全发挥作用。将药物包裹在微球中可以减缓药物释放的速度并延长药物的疗效。溶剂蒸发法因操作简单、设备要求低而被广泛用于制备蛋白质/肽类微球。然而，该方法在较低的包封效率、不稳定的释放曲线以及蛋白质/肽类的稳定性方面存在一些挑战，研究人员认为可以通过调整微球的制备参数或配方来解决这些问题。本文讨论了通过溶剂蒸发法制备载蛋白质/肽类微球的配方参数，概述了目前用于蛋白质/肽类微球的溶剂蒸发的有前景的策略。本文以参数评估为框架，便于后续研究人员在遇到问题时快速找到可能的解决方案。
