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Exploring the potential of Salmonella-mediated anti-sense RCAS1 RNA therapy in combatting aggressive breast cancer.

作者信息

Senevirathne Amal, Hajam Irshad A

机构信息

Chungnam National University, Yuseong-go, Daejeopn 34134, Republic of Korea.

Department of Pediatrics, University of California San Diego, San Diego, CA 92093, USA.

出版信息

Mol Ther Nucleic Acids. 2023 Dec 15;35(1):102089. doi: 10.1016/j.omtn.2023.102089. eCollection 2024 Mar 12.

DOI:10.1016/j.omtn.2023.102089
PMID:38178917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10765041/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082a/10765041/5c199e0de0c1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082a/10765041/5c199e0de0c1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082a/10765041/5c199e0de0c1/gr1.jpg

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Mol Ther Nucleic Acids. 2023 Dec 15;35(1):102089. doi: 10.1016/j.omtn.2023.102089. eCollection 2024 Mar 12.
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Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic inhibited 4T1 breast tumors and metastasis in mice.通过减毒的色氨酸营养缺陷型细菌实现针对RCAS1的lnc反义RNA的肿瘤靶向递送,可抑制小鼠4T1乳腺肿瘤及其转移。
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本文引用的文献

1
Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic inhibited 4T1 breast tumors and metastasis in mice.通过减毒的色氨酸营养缺陷型细菌实现针对RCAS1的lnc反义RNA的肿瘤靶向递送,可抑制小鼠4T1乳腺肿瘤及其转移。
Mol Ther Nucleic Acids. 2023 Oct 13;34:102053. doi: 10.1016/j.omtn.2023.102053. eCollection 2023 Dec 12.
2
The complex role of tumor-infiltrating macrophages.肿瘤浸润巨噬细胞的复杂作用。
Nat Immunol. 2022 Aug;23(8):1148-1156. doi: 10.1038/s41590-022-01267-2. Epub 2022 Jul 25.
3
Noncoding RNA therapeutics - challenges and potential solutions.
非编码 RNA 治疗学——挑战与潜在解决方案。
Nat Rev Drug Discov. 2021 Aug;20(8):629-651. doi: 10.1038/s41573-021-00219-z. Epub 2021 Jun 18.
4
-Mediated Cancer Therapy: An Innovative Therapeutic Strategy.介导的癌症治疗:一种创新的治疗策略。
J Cancer. 2019 Aug 20;10(20):4765-4776. doi: 10.7150/jca.32650. eCollection 2019.
5
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.肠道微生物群调节环磷酰胺的抗癌免疫作用。
Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537.
6
The Involvement of RCAS1 in Creating a Suppressive Tumor Microenvironment in Patients with Salivary Gland Adenocarcinoma.RCAS1在涎腺腺癌患者中参与构建抑制性肿瘤微环境
Cancer Microenviron. 2010 Aug 20;4(1):13-21. doi: 10.1007/s12307-010-0051-6.
7
Serodiagnosis of Salmonella enterica serovar Typhi and S. enterica serovars Paratyphi A, B and C human infections.伤寒沙门氏菌、甲型副伤寒沙门氏菌、乙型副伤寒沙门氏菌和丙型副伤寒沙门氏菌人类感染的血清学诊断。
J Med Microbiol. 2007 Sep;56(Pt 9):1161-1166. doi: 10.1099/jmm.0.47197-0.
8
The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas.威廉·B·科利毒素与骨和软组织肉瘤的治疗
Iowa Orthop J. 2006;26:154-8.
9
RCAS1 is associated with ductal breast cancer progression.RCAS1与乳腺导管癌进展相关。
Biochem Biophys Res Commun. 2002 May 24;293(5):1544-9. doi: 10.1016/S0006-291X(02)00401-1.
10
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Nat Med. 1999 Aug;5(8):938-42. doi: 10.1038/11383.