Fitzgerald R H, Kelly P J
Mayo Clin Proc. 1979 Sep;54(9):590-6.
Hypersensitivity reactions and deep sepsis are the primary forms of biologic failure of total joint arthroplasty. Hypersensitivity reactions appear to be related to metal debris associated with metal articulating with metal arthroplasties. Although the incidence of deep sepsis following total joint arthroplasty is lower than initially feared, it remains a serious problem for both the patient and the surgeon. Fixation of prosthetic devices with methyl methacrylate appears safe. However, improved methods of fixation which are more compatible with osseous tissue are currently under study. The advantages of porous materials and the results of laboratory studies are reviewed.
超敏反应和深部脓毒症是全关节置换术生物性失败的主要形式。超敏反应似乎与金属对金属关节成形术产生的金属碎屑有关。尽管全关节置换术后深部脓毒症的发生率低于最初的担忧，但对患者和外科医生来说仍是一个严重问题。用甲基丙烯酸甲酯固定假体装置似乎是安全的。然而，目前正在研究与骨组织更相容的改进固定方法。本文综述了多孔材料的优点及实验室研究结果。
