Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Division of General Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Hernia. 2024 Apr;28(2):517-526. doi: 10.1007/s10029-023-02944-3. Epub 2024 Jan 5.
Frailty has shown promise in predicting postoperative morbidity and mortality following hernia surgery. This study aims to evaluate the predictive capacity of the 11-item modified frailty index (mFI) in estimating postoperative outcomes following elective hernia surgery using the National Inpatient Sample (NIS) database.
A retrospective analysis of the NIS from 2015 to 2019 was performed including adult patients who underwent elective hernia repair. The mFI was used to stratify patients as either frail (mFI ≥ 0.27) or robust (mFI < 0.27). The primary outcomes were in-hospital postoperative morbidity and mortality. The secondary outcomes were system-specific morbidity, length of stay (LOS), total in-hospital healthcare cost, and discharge disposition. Univariable and multivariable regressions were utilized.
In total, 14,125 robust patients and 1704 frail patients were included. Frailty was associated with an increased age (mean age 66.4 years vs. 52.6 years, p < 0.001) and prevalence of ventral hernias (51.9% vs. 44.4%, p < 0.001). Adjusted analyses demonstrated that frail patients had increased in-hospital mortality (adjusted odds ratio (aOR) 3.89, 95% CI 1.50, 10.11, p = 0.005), postoperative overall morbidity (aOR 1.98, 95% CI 1.72, 2.29, p < 0.001), postoperative LOS (adjusted mean difference (aMD) 0.78 days, 95% CI 0.51, 1.06, p < 0.001), total in-hospital healthcare costs (aMD $7562 95% CI 3292, 11,832, p = 0.001), and were less likely to be discharged home (aOR 0.61, 95% CI 0.53, 0.69, p < 0.001).
The mFI may be a reliable predictor of postoperative morbidity and mortality in elective hernia surgery. Utilizing this tool can aid in patient education and identifying high-risk patients who may benefit from tailored prehabilitation.
衰弱在预测疝手术后的发病率和死亡率方面显示出了一定的前景。本研究旨在使用国家住院患者样本(NIS)数据库评估 11 项改良衰弱指数(mFI)在评估择期疝手术后术后结果方面的预测能力。
对 2015 年至 2019 年 NIS 进行回顾性分析,纳入接受择期疝修复的成年患者。使用 mFI 将患者分为虚弱(mFI≥0.27)或强壮(mFI<0.27)。主要结局为住院术后发病率和死亡率。次要结局为系统特异性发病率、住院时间(LOS)、总住院医疗费用和出院去向。使用单变量和多变量回归。
共纳入 14125 名强壮患者和 1704 名虚弱患者。虚弱与年龄较大(平均年龄 66.4 岁 vs. 52.6 岁,p<0.001)和腹疝患病率较高(51.9% vs. 44.4%,p<0.001)相关。调整分析表明,虚弱患者的住院死亡率更高(调整后优势比(aOR)3.89,95%置信区间(CI)1.50,10.11,p=0.005),术后总发病率更高(aOR 1.98,95% CI 1.72,2.29,p<0.001),术后 LOS 更长(调整平均差(aMD)0.78 天,95% CI 0.51,1.06,p<0.001),总住院医疗费用更高(aMD 7562 美元 95% CI 3292,11832,p=0.001),出院回家的可能性更低(aOR 0.61,95% CI 0.53,0.69,p<0.001)。
mFI 可能是预测择期疝手术术后发病率和死亡率的可靠指标。使用该工具可以帮助患者教育,并识别可能受益于定制康复的高危患者。