Division of General Surgery, McMaster University, Hamilton, Ontario, Canada.
Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Dis Esophagus. 2023 Oct 27;36(11). doi: 10.1093/dote/doad038.
Previous studies recommend a watch-and-wait approach to paraesophageal hernia (PEH) repair due to an increased risk for mortality. While contemporary studies suggest that elective surgery is safe and effective, many patients presenting with PEH are elderly. Therefore, we assessed the impact of frailty on in-hospital outcomes and healthcare utilization among patients receiving PEH repair. This retrospective population-based cohort study assessed patients from the National Inpatient Sample database who received PEH repair between October 2015 to December 2019. Demographic and perioperative data were gathered, and frailty was measured using the 11-item modified frailty index. The outcomes measured were in-hospital mortality, complications, discharge disposition, and healthcare utilization. Overall, 10,716 patients receiving PEH repair were identified, including 1442 frail patients. Frail patients were less often female and were more often in the lowest income quartile compared to robust patients. Frail patients were at greater odds for in-hospital mortality [odds ratio (OR) 2.83 (95% CI 1.65-4.83); P < 0.001], postoperative ICU admissions [OR 2.07 (95% CI 1.55-2.78); P < 0.001], any complications [OR 2.18 (95% CI 1.55-2.78); P < 0.001], hospital length of stay [mean difference (MD) 1.75 days (95% CI 1.30-2.210; P < 0.001], and total admission costs [MD $5631.65 (95% CI $3300.06-$7.963.24); P < 0.001] relative to their robust patients. While PEH repair in elderly patients is safe and effective, frail patients have an increased rate of in-hospital mortality, postoperative ICU admissions, complications, and total admission costs. Clinicians should consider patient frailty when identifying the most appropriate surgical candidates for PEH repair.
先前的研究建议采用观察等待的方法来修复食管旁疝(PEH),因为这种方法的死亡率更高。虽然当代的研究表明,择期手术是安全有效的,但许多患有 PEH 的患者年龄较大。因此,我们评估了脆弱性对接受 PEH 修复的患者住院期间结局和医疗保健利用的影响。这项回顾性基于人群的队列研究评估了 2015 年 10 月至 2019 年 12 月期间在国家住院患者样本数据库中接受 PEH 修复的患者。收集了人口统计学和围手术期数据,并使用 11 项改良的脆弱性指数来衡量脆弱性。测量的结果是住院死亡率、并发症、出院去向和医疗保健利用。总的来说,确定了 10716 名接受 PEH 修复的患者,其中包括 1442 名脆弱患者。与强壮患者相比,脆弱患者中女性患者较少,且更常处于最低收入四分位数。脆弱患者住院死亡率更高[比值比(OR)2.83(95%置信区间 1.65-4.83);P<0.001],术后 ICU 入住率更高[OR 2.07(95%置信区间 1.55-2.78);P<0.001],任何并发症发生率更高[OR 2.18(95%置信区间 1.55-2.78);P<0.001],住院时间更长[平均差异(MD)1.75 天(95%置信区间 1.30-2.210;P<0.001)],总入院费用更高[MD $5631.65(95%置信区间 3300.06-$7963.24);P<0.001],与他们强壮的患者相比。虽然老年患者的 PEH 修复是安全有效的,但脆弱患者的住院死亡率、术后 ICU 入住率、并发症和总入院费用更高。临床医生在确定最适合接受 PEH 修复的手术患者时,应考虑患者的脆弱性。