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MAGE-A11 是胃癌潜在的预后生物标志物和免疫治疗靶点。

MAGE-A11 is a potential prognostic biomarker and immunotherapeutic target in gastric cancer.

机构信息

Institute of Biology and Medicine, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430081, Hubei, P.R. China.

Key Laboratory of Chronic Noncommunicable Diseases, Yueyang Vocational Technical College, Yueyang 414006, Hunan, P.R. China.

出版信息

Aging (Albany NY). 2024 Jan 4;16(1):285-298. doi: 10.18632/aging.205368.

DOI:10.18632/aging.205368
PMID:38180746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10817374/
Abstract

Gastric cancer poses a serious threat to human health and affects the digestive system. The lack of early symptoms and a dearth of effective identification methods make diagnosis difficult, with many patients only receiving a definitive diagnosis at a malignant stage, causing them to miss out on optimal therapeutic interventions. Melanoma-associated antigen-A (MAGE-A) is part of the MAGE family and falls under the cancer/testis antigen (CTA) category. The MAGE-A subfamily plays a significant role in tumorigenesis, proliferation and migration. The expression, prognosis and function of MAGE-A family members in GC, however, remain unclear. Our research and screening have shown that MAGE-A11 was highly expressed in GC tissues and was associated with poor patient prognosis. Additionally, MAGE-A11 functioned as an independent prognostic factor in GC through Cox regression analysis, and its expression showed significant correlation with both tumour immune cell infiltration and responsiveness to immunotherapy. Our data further indicated that MAGE-A11 regulated GC cell proliferation and migration. Subsequently, our findings propose that MAGE-A11 may operate as a prognostic factor, having potential as an immunotherapy target for GC.

摘要

胃癌严重威胁人类健康，影响消化系统。由于早期症状不明显，且缺乏有效的识别方法，导致诊断困难，许多患者在恶性阶段才得到明确诊断，错失了最佳治疗干预的机会。黑色素瘤相关抗原-A（MAGE-A）是 MAGE 家族的一部分，属于癌症/睾丸抗原（CTA）类别。MAGE-A 亚家族在肿瘤发生、增殖和迁移中发挥重要作用。然而，MAGE-A 家族成员在 GC 中的表达、预后和功能尚不清楚。我们的研究和筛选表明，MAGE-A11 在 GC 组织中高表达，与患者预后不良相关。此外，通过 Cox 回归分析，MAGE-A11 作为 GC 的独立预后因素，其表达与肿瘤免疫细胞浸润和对免疫治疗的反应性均呈显著相关。我们的数据进一步表明，MAGE-A11 调节 GC 细胞的增殖和迁移。随后，我们的研究结果表明，MAGE-A11 可能作为一个预后因素发挥作用，具有作为 GC 免疫治疗靶点的潜力。

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Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma.
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