KRAS 之旅：在同基因胰腺类器官中研究代谢重编程。
The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids.
机构信息
Department of Internal Medicine, University of Chicago, Chicago, IL, USA.
Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA.
出版信息
Cell Stem Cell. 2024 Jan 4;31(1):1-2. doi: 10.1016/j.stem.2023.12.010.
PMID:38181746
Abstract
Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.
摘要
使用同源器官模型来模拟胰腺癌，段等人在突变型 KRAS 和胆固醇代谢之间建立了一个重要联系，并确定丙戊酸钠作为一种可能的治疗靶点。
Zotero 插件